开源微型封盖机可精准完成密闭空间内样品封盖,性能媲美工业设备。
An Open-source Capping Machine Suitable for Confined Spaces
- 设计紧凑型开源封盖机,集成视觉系统检测封盖失败
- 100次开闭测试成功率100%,密封性优于人工和工业设备
- 适合预算有限或空间受限的自动化实验室使用
在自主实验室内,自动且无误的封盖是样品制备中的常见步骤。尽管自驱动实验室中的封盖操作可在大空间或小空间(如通风柜内)进行,但大多数商用封盖机主要针对大空间设计,体积过大,难以适应狭小环境。此外,许多商用产品为闭源,难以融入完全自动化的流程。本文提出一种适用于紧凑空间的开源封盖机,并集成视觉系统以识别封盖失败。通过各重复100次的封盖与开盖测试,该机器实现了100%的成功率。进一步测试中,对12支装有不同蒸气压溶剂(水、乙醇、丙酮)的试管进行封盖,并每3小时称重一次,持续3天。结果表明,原型机封盖的试管平均每日失重0.54%,而工业设备(Chemspeed站)和人工封盖分别为0.0078%和0.013%。对比显示,该装置在空间与成本受限的自驱动实验室中,是工业与人工封盖的合理替代方案。
原文摘要 · Abstract (English)
In the context of self-driving laboratories (SDLs), ensuring automated and error-free capping is crucial, as it is a ubiquitous step in sample preparation. Automated capping in SDLs can occur in both large and small workspaces (e.g., inside a fume hood). However, most commercial capping machines are designed primarily for large spaces and are often too bulky for confined environments. Moreover, many commercial products are closed-source, which can make their integration into fully autonomous workflows difficult. This paper introduces an open-source capping machine suitable for compact spaces, which also integrates a vision system that recognises capping failure. The capping and uncapping processes are repeated 100 times each to validate the machine's design and performance. As a result, the capping machine reached a 100 % success rate for capping and uncapping. Furthermore, the machine sealing capacities are evaluated by capping 12 vials filled with solvents of different vapour pressures: water, ethanol and acetone. The vials are then weighed every 3 hours for three days. The machine's performance is benchmarked against an industrial capping machine (a Chemspeed station) and manual capping. The vials capped with the prototype lost 0.54 % of their content weight on average per day, while the ones capped with the Chemspeed and manually lost 0.0078 % and 0.013 %, respectively. The results show that the capping machine is a reasonable alternative to industrial and manual capping, especially when space and budget are limitations in SDLs.
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