用扩散模型提升4D MRI时间分辨率,同时保持空间一致性。
A Diffusion-Driven Temporal Super-Resolution and Spatial Consistency Enhancement Framework for 4D MRI imaging
- 基于扩散模型的时序超分辨率,单步实现6倍时间分辨率提升。
- 引入三向Mamba模块,解决跨切片错位导致的空间不一致问题。
- 适用于心脏和关节等快速运动场景的高保真动态MRI重建。
在医学成像中,4D MRI可实现动态三维可视化,但时空分辨率权衡导致扫描时间延长,尤其在快速大范围运动时影响时间保真度。传统方法依赖配准插值生成中间帧,但在大形变下易出现配准错误、伪影和空间不一致。为此,本文提出TSSC-Net框架,在生成中间帧的同时保持空间一致性。为提升快速运动下的时间保真度,采用基于扩散的时序超分辨率网络,以首尾帧为参考,单次推理实现6倍时间超分辨率。此外,设计一种新型三向Mamba模块,利用长程上下文信息有效解决跨切片错位引起的空间不一致问题,增强体数据一致性并修正跨切片误差。在公开的ACDC心脏MRI数据集和真实动态膝关节4D MRI数据集上进行了大量实验,结果表明TSSC-Net能从快速运动数据中生成高分辨率动态MRI,同时保持结构保真度与空间一致性。
原文摘要 · Abstract (English)
In medical imaging, 4D MRI enables dynamic 3D visualization, yet the trade-off between spatial and temporal resolution requires prolonged scan time that can compromise temporal fidelity--especially during rapid, large-amplitude motion. Traditional approaches typically rely on registration-based interpolation to generate intermediate frames. However, these methods struggle with large deformations, resulting in misregistration, artifacts, and diminished spatial consistency. To address these challenges, we propose TSSC-Net, a novel framework that generates intermediate frames while preserving spatial consistency. To improve temporal fidelity under fast motion, our diffusion-based temporal super-resolution network generates intermediate frames using the start and end frames as key references, achieving 6x temporal super-resolution in a single inference step. Additionally, we introduce a novel tri-directional Mamba-based module that leverages long-range contextual information to effectively resolve spatial inconsistencies arising from cross-slice misalignment, thereby enhancing volumetric coherence and correcting cross-slice errors. Extensive experiments were performed on the public ACDC cardiac MRI dataset and a real-world dynamic 4D knee joint dataset. The results demonstrate that TSSC-Net can generate high-resolution dynamic MRI from fast-motion data while preserving structural fidelity and spatial consistency.
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