用全程时间延时视频实现胚胎整体质量评分,更贴近临床判断。
Time-Lapse Video-Based Embryo Grading via Complementary Spatial-Temporal Pattern Mining
- 通过时空互补特征挖掘,融合形态与发育动态信息
- 在2500+真实临床视频上达到优于现有方法的评分准确率
- 适合辅助生殖领域研究者和医生参考应用
人工智能在体外受精(IVF)自动化胚胎筛选中展现出潜力。然而,现有方法或仅评估部分指标而缺乏整体质量判断,或针对临床结局但受胚外因素干扰,限制了实际应用。为此,我们提出全新任务:基于时间延时监控(TLM)视频的胚胎评级——首个直接利用完整时长视频预测胚胎学家整体质量评分的范式。为此,我们构建了一个包含超过2,500个TLM视频的真实临床数据集,每个视频均标注有反映胚胎整体质量的评分标签。基于临床决策原理,提出互补时空模式挖掘(CoSTeM)框架,模拟胚胎学家评估流程。该框架包含两分支:(1) 形态分支,采用交叉注意力专家混合层与时间选择模块,提取具有判别性的局部结构特征;(2) 形态动力学分支,使用时间变换器建模全局发育轨迹,协同整合静态与动态决定因素进行评分。大量实验验证了设计优势。本工作为人工智能辅助胚胎筛选提供重要方法框架。数据集与源代码将在论文接受后公开。
原文摘要 · Abstract (English)
Artificial intelligence has recently shown promise in automated embryo selection for In-Vitro Fertilization (IVF). However, current approaches either address partial embryo evaluation lacking holistic quality assessment or target clinical outcomes inevitably confounded by extra-embryonic factors, both limiting clinical utility. To bridge this gap, we propose a new task called Video-Based Embryo Grading - the first paradigm that directly utilizes full-length time-lapse monitoring (TLM) videos to predict embryologists' overall quality assessments. To support this task, we curate a real-world clinical dataset comprising over 2,500 TLM videos, each annotated with a grading label indicating the overall quality of embryos. Grounded in clinical decision-making principles, we propose a Complementary Spatial-Temporal Pattern Mining (CoSTeM) framework that conceptually replicates embryologists' evaluation process. The CoSTeM comprises two branches: (1) a morphological branch using a Mixture of Cross-Attentive Experts layer and a Temporal Selection Block to select discriminative local structural features, and (2) a morphokinetic branch employing a Temporal Transformer to model global developmental trajectories, synergistically integrating static and dynamic determinants for grading embryos. Extensive experimental results demonstrate the superiority of our design. This work provides a valuable methodological framework for AI-assisted embryo selection. The dataset and source code will be publicly available upon acceptance.
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