arXiv:2506.10212cs.LGcs.AI2025-06被引 4

用心电与心音数据互推,发现心音可预测心电关键指标。

Cross-Learning Between ECG and PCG: Exploring Common and Exclusive Characteristics of Bimodal Electromechanical Cardiac Waveforms

  • 用非因果LSTM等模型实现心电与心音相互重建,非线性模型效果更优。
  • 心音重建心电比反向重建更准确,运动状态和个体差异影响显著。
  • 基于包络特征的建模提升跨人泛化能力,可从心音估计QT间隔等临床指标。

同步心电图(ECG)与心音图(PCG)分别捕捉心脏电活动与机械活动,提供全面的心脏功能多模态视角。然而,两者间信息的共性与独有特性,以及在不同生理状态和个体间互为重建与生物标志物提取的潜力仍不明确。本研究基于同时采集的静息与运动状态下ECG-PCG数据(EPHNOGRAM数据集),采用线性与非线性机器学习模型(包括非因果LSTM网络),系统分析两模态间相互重建性能,探究时序因果性、生理状态及跨个体变异的影响。结果表明,非线性模型(尤其是非因果LSTM)重建表现更优,由心音重建心电优于反向重建。运动状态与跨个体场景带来显著挑战,但基于瞬时幅值特征的包络建模显著提升了跨个体泛化能力。进一步验证了在跨个体条件下,心音可有效估计心电关键生物标志物,如波峰点与QT间期。该研究深化了对心电与心音之间波形特性和心脏事件时序关系的理解,为新型多模态心脏监测技术提供了理论基础。

原文摘要 · Abstract (English)

Simultaneous electrocardiography (ECG) and phonocardiogram (PCG) provide a comprehensive, multimodal perspective on cardiac function by capturing the heart's electrical and mechanical activities, respectively. However, the distinct and overlapping information content of these signals, as well as their potential for mutual reconstruction and biomarker extraction, remains incompletely understood, especially under varying physiological conditions and across individuals. In this study, we systematically investigate the common and exclusive characteristics of ECG and PCG using the EPHNOGRAM dataset of simultaneous ECG-PCG recordings during rest and exercise. We employ a suite of linear and nonlinear machine learning models, including non-causal LSTM networks, to reconstruct each modality from the other and analyze the influence of causality, physiological state, and cross-subject variability. Our results demonstrate that nonlinear models, particularly non-causal LSTM, provide superior reconstruction performance, with reconstructing ECG from PCG proving more tractable than the reverse. Exercise and cross-subject scenarios present significant challenges, but envelope-based modeling that utilizes instantaneous amplitude features substantially improves cross-subject generalizability for cross-modal learning. Furthermore, we demonstrate that clinically relevant ECG biomarkers, such as fiducial points and QT intervals, can be estimated from PCG in cross-subject settings. These findings advance our understanding of the relationship between electromechanical cardiac modalities, in terms of both waveform characteristics and the timing of cardiac events, with potential applications in novel multimodal cardiac monitoring technologies.

多模态心电图心音图跨个体

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