HERCULES实现超声3D大范围成像，突破传统阵列视野限制。
Hadamard Encoded Row Column Ultrasonic Expansive Scanning (HERCULES) with Bias-Switchable Row-Column Arrays
- 利用哈达玛编码与可切换偏压阵列，实现全二维合成接收孔径成像。
- 仿真与实验均证明可实现每秒数十至数百帧的高帧率成像。
- 适合需要大体积实时3D成像的生物医学研究，如器官结构可视化。
顶对底电极（TOBE）阵列，又称可切换偏压行-列阵列（RCAs），使非可切换偏压的RCAs无法实现的成像技术成为可能。新型成像技术赫尔克勒斯（HERCULES）通过发射平面或柱面波前，并采用哈达玛编码读出（HERO）进行接收，实现等效于完整二维合成接收孔径的波束成形，从而实现超越RCAs阵列孔径阴影的扩展3D扫描。该技术有望实现整个器官的成像和组织形态的三维可视化，同时可在有限窗口下观测大体积区域。本文通过仿真证明，该方法可在每秒数十至数百帧的速度下达到与现有RCAs成像方法相当的分辨率。通过自研的TOBE阵列、偏压电子器件及科研超声系统，实现了实验验证。进一步使用商用模型体进行成像，并与传统RCAs方法对比。最后，通过小鼠异种移植模型验证了其真实组织成像能力。
原文摘要 · Abstract (English)
Top-Orthogonal-to-Bottom-Electrode (TOBE) arrays, also known as bias-switchable row-column arrays (RCAs), allow for imaging techniques otherwise impossible for non-bias-switachable RCAs. Hadamard Encoded Row Column Ultrasonic Expansive Scanning (HERCULES) is a novel imaging technique that allows for expansive 3D scanning by transmitting plane or cylindrical wavefronts and receiving using Hadamard-Encoded-Read-Out (HERO) to perform beamforming on what is effectively a full 2D synthetic receive aperture. This allows imaging beyond the shadow of the aperture of the RCA array, potentially allows for whole organ imaging and 3D visualization of tissue morphology. It additionally enables view large volumes through limited windows. In this work we demonstrated with simulation that we are able to image at comparable resolution to existing RCA imaging methods at tens to hundreds of volumes per second. We validated these simulations by demonstrating an experimental implementation of HERCULES using a custom fabricated TOBE array, custom biasing electronics, and a research ultrasound system. Furthermore, we assess our imaging capabilities by imaging a commercial phantom, and comparing our results to those taken with traditional RCA imaging methods. Finally, we verified our ability to image real tissue by imaging a xenograft mouse model.
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