用AI自动查询非标准生物数据库,让科研人员轻松整合多源数据。
A GenAI System for Improved FAIR Independent Biological Database Integration
- 通过自然语言理解,自动匹配文献中的数据库并生成可执行查询
- 支持非FAIR标准数据源的智能接入与高质量结果输出
- 适合生物信息学研究者快速验证科学假设
生命科学研究日益依赖从不断演化的链接开放数据(LOD)网络中识别、访问和有效处理数据。这一动态环境给研究人员带来巨大负担,因为查询结果质量高度依赖于数据源的选择与语义集成——这些过程通常费时、易错且成本高。尽管FAIR(可发现、可访问、可互操作、可重用)数据原则旨在解决此类挑战,但高效准确的数据处理障碍依然存在。本文提出FAIRBridge,一个基于自然语言的实验性查询处理系统,旨在帮助科学家在无需数据源为FAIR合规的情况下,仍能发现、访问并查询生物数据库。FAIRBridge利用AI解析查询意图,将之映射至科学文献中描述的相关数据库,并通过智能资源访问计划生成可执行查询。系统还配备强大工具以缓解低质量查询处理问题,确保信息交付的高保真度与响应性。其自主查询处理框架使用户能够探索替代数据源,在每一步做出知情决策,并在需要时借助社区驱动的众包校验。通过提供一个以自然英语操作的友好型自动化假说检验平台,FAIRBridge显著提升了科学数据的整合与处理效率,为研究者提供了推进科学探究的强大新工具。
原文摘要 · Abstract (English)
Life sciences research increasingly requires identifying, accessing, and effectively processing data from an ever-evolving array of information sources on the Linked Open Data (LOD) network. This dynamic landscape places a significant burden on researchers, as the quality of query responses depends heavily on the selection and semantic integration of data sources --processes that are often labor-intensive, error-prone, and costly. While the adoption of FAIR (Findable, Accessible, Interoperable, and Reusable) data principles has aimed to address these challenges, barriers to efficient and accurate scientific data processing persist. In this paper, we introduce FAIRBridge, an experimental natural language-based query processing system designed to empower scientists to discover, access, and query biological databases, even when they are not FAIR-compliant. FAIRBridge harnesses the capabilities of AI to interpret query intents, map them to relevant databases described in scientific literature, and generate executable queries via intelligent resource access plans. The system also includes robust tools for mitigating low-quality query processing, ensuring high fidelity and responsiveness in the information delivered. FAIRBridge's autonomous query processing framework enables users to explore alternative data sources, make informed choices at every step, and leverage community-driven crowd curation when needed. By providing a user-friendly, automated hypothesis-testing platform in natural English, FAIRBridge significantly enhances the integration and processing of scientific data, offering researchers a powerful new tool for advancing their inquiries.
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