为药剂师打造的药物信息知识图谱,整合多源数据提升临床决策能力。
medicX-KG: A Knowledge Graph for Pharmacists' Drug Information Needs
- 基于药剂师需求设计,融合英国药品目录等三类数据源
- 支持药物可及性、相互作用等查询,准确率高且可解释
- 适合临床药学、医药监管领域研究者与从业者使用
药剂师角色正从发药转向多学科医疗团队中的综合药学服务。这一转变依赖于准确、实时的药品信息,需通过强大的数据整合支撑。本文提出medicX-KG,一个面向药剂师的知识图谱,支持临床与监管决策,作为medicX平台的语义层,驱动预测与可解释的药学服务。该图谱整合英国国家处方集(BNF)、DrugBank及马耳他药品管理局(MMA)数据,覆盖马耳他的监管环境,并兼顾欧洲药品管理局标准与部分英国供应依赖。针对国内缺乏统一药品数据库的问题,有效减少药剂师对碎片化信息源的依赖。其设计基于对执业药剂师的访谈,确保实用性。文中详述了数据抽取、本体设计与语义映射流程。评估表明,medicX-KG在药物可及性、相互作用、不良反应和治疗类别查询上表现良好。局限包括缺乏详细剂量编码与实时更新,未来将优化。
原文摘要 · Abstract (English)
The role of pharmacists is evolving from medicine dispensing to delivering comprehensive pharmaceutical services within multidisciplinary healthcare teams. Central to this shift is access to accurate, up-to-date medicinal product information supported by robust data integration. Leveraging artificial intelligence and semantic technologies, Knowledge Graphs (KGs) uncover hidden relationships and enable data-driven decision-making. This paper presents medicX-KG, a pharmacist-oriented knowledge graph supporting clinical and regulatory decisions. It forms the semantic layer of the broader medicX platform, powering predictive and explainable pharmacy services. medicX-KG integrates data from three sources, including, the British National Formulary (BNF), DrugBank, and the Malta Medicines Authority (MMA) that addresses Malta's regulatory landscape and combines European Medicines Agency alignment with partial UK supply dependence. The KG tackles the absence of a unified national drug repository, reducing pharmacists' reliance on fragmented sources. Its design was informed by interviews with practicing pharmacists to ensure real-world applicability. We detail the KG's construction, including data extraction, ontology design, and semantic mapping. Evaluation demonstrates that medicX-KG effectively supports queries about drug availability, interactions, adverse reactions, and therapeutic classes. Limitations, including missing detailed dosage encoding and real-time updates, are discussed alongside directions for future enhancements.
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