arXiv:2506.19181eess.IV2025-06

用哈达玛变换提升腹部MRI偏置场校正效果,更准更快。

VHU-Net: Variational Hadamard U-Net for Body MRI Bias Field Correction

  • 通过哈达玛变换分解通道频率,分离低频偏置场
  • 新提出的变分下界使潜空间稀疏,提升校正精度
  • 兼顾效率与可解释性,适合临床多中心部署

磁共振成像(MRI)中的偏置场伪影会导致空间平滑的强度不均,降低图像质量并影响后续分析。为解决此问题,我们提出一种新型变分哈达玛U-Net(VHU-Net),用于有效校正腹部MRI偏置场。编码器包含多个卷积哈达玛变换模块(ConvHTBlocks),每个模块结合卷积层与哈达玛变换(HT)层,其中HT层实现通道级频率分解以提取低频成分,随后的缩放层与半软阈值机制抑制冗余高频噪声。为弥补HT层无法建模通道间依赖的问题,解码器引入逆哈达玛重构变压器块,实现全局、频率感知的注意力机制,以恢复空间一致的偏置场。堆叠的解码器ConvHTBlocks进一步增强对真实偏置场的重建能力。基于变分推断原理,我们构建新的证据下界(ELBO)作为训练目标,在保证偏置场估计准确的同时促进潜空间稀疏性。在多个腹部MRI数据集上的实验表明,VHU-Net在强度均匀性方面优于现有最先进方法,且校正后的图像显著提升分割精度。该框架具备计算高效、可解释性强及跨多中心数据集鲁棒表现的特点,适合临床部署。

原文摘要 · Abstract (English)

Bias field artifacts in magnetic resonance imaging (MRI) scans introduce spatially smooth intensity inhomogeneities that degrade image quality and hinder downstream analysis. To address this challenge, we propose a novel variational Hadamard U-Net (VHU-Net) for effective body MRI bias field correction. The encoder comprises multiple convolutional Hadamard transform blocks (ConvHTBlocks), each integrating convolutional layers with a Hadamard transform (HT) layer. Specifically, the HT layer performs channel-wise frequency decomposition to isolate low-frequency components, while a subsequent scaling layer and semi-soft thresholding mechanism suppress redundant high-frequency noise. To compensate for the HT layer's inability to model inter-channel dependencies, the decoder incorporates an inverse HT-reconstructed transformer block, enabling global, frequency-aware attention for the recovery of spatially consistent bias fields. The stacked decoder ConvHTBlocks further enhance the capacity to reconstruct the underlying ground-truth bias field. Building on the principles of variational inference, we formulate a new evidence lower bound (ELBO) as the training objective, promoting sparsity in the latent space while ensuring accurate bias field estimation. Comprehensive experiments on body MRI datasets demonstrate the superiority of VHU-Net over existing state-of-the-art methods in terms of intensity uniformity. Moreover, the corrected images yield substantial downstream improvements in segmentation accuracy. Our framework offers computational efficiency, interpretability, and robust performance across multi-center datasets, making it suitable for clinical deployment.

MRI校正哈达玛变换深度学习偏置场

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