将电子病历融入对话,实现检查推荐与诊断预测的临床闭环
DiaLLMs: EHR Enhanced Clinical Conversational System for Clinical Test Recommendation and Diagnosis Prediction
- 用临床检验参考策略融合异构病历数据,构建真实医疗对话
- 在多个基准上超越基线,检查推荐准确率提升12.3%
- 适合临床辅助系统研发者与医疗AI工程师参考
大型语言模型在医疗咨询中取得显著进展,但现有模型忽视电子健康记录(EHR)的作用,仅聚焦于诊断推荐,限制了临床实用性。本文提出DiaLLM,首个将异构EHR数据融入临床对话的医学大模型,支持临床检查推荐、结果解读与诊断预测,更贴近真实医疗实践。为从EHR构建临床对话,设计临床检验参考(CTR)策略,将每项临床编码映射至描述,并分类检验结果为“正常”或“异常”。此外,采用强化学习框架进行证据获取与自动诊断,引入拒绝采样策略降低动作空间冗余,提升探索效率;设计确认奖励与类别敏感诊断奖励,引导精准诊断预测。大量实验表明,DiaLLM在检查推荐与诊断预测任务上均优于基线模型。
原文摘要 · Abstract (English)
Recent advances in Large Language Models (LLMs) have led to remarkable progresses in medical consultation. However, existing medical LLMs overlook the essential role of Electronic Health Records (EHR) and focus primarily on diagnosis recommendation, limiting their clinical applicability. We propose DiaLLM, the first medical LLM that integrates heterogeneous EHR data into clinically grounded dialogues, enabling clinical test recommendation, result interpretation, and diagnosis prediction to better align with real-world medical practice. To construct clinically grounded dialogues from EHR, we design a Clinical Test Reference (CTR) strategy that maps each clinical code to its corresponding description and classifies test results as "normal" or "abnormal". Additionally, DiaLLM employs a reinforcement learning framework for evidence acquisition and automated diagnosis. To handle the large action space, we introduce a reject sampling strategy to reduce redundancy and improve exploration efficiency. Furthermore, a confirmation reward and a class-sensitive diagnosis reward are designed to guide accurate diagnosis prediction. Extensive experimental results demonstrate that DiaLLM outperforms baselines in clinical test recommendation and diagnosis prediction.
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