用影像数据快速生成个性化心脏力学模型,精度更高且省时。
IMC-PINN-FE: A Physics-Informed Neural Network for Patient-Specific Left Ventricular Finite Element Modeling with Image Motion Consistency and Biomechanical Parameter Estimation

- 结合医学影像与物理规律的神经网络,自动估算心肌刚度和收缩力。
- 相比传统方法提速75倍,匹配影像位移的平均Dice提升至0.927。
- 无需大量数据即可实现个体化建模,适合临床精准诊断使用。
理解心肌生物力学行为对认识心脏生理至关重要,但无法直接从临床影像中获取,通常依赖有限元(FE)模拟。然而传统FE方法计算成本高,难以还原观测到的心脏运动。本文提出IMC-PINN-FE,一种融合影像运动一致性(IMC)与有限元建模的物理信息神经网络框架。首先利用MRI或超声心动图,通过预训练注意力网络或无监督循环正则化网络估计心脏运动并提取运动模态;随后通过拟合临床压力数据,快速估算心肌刚度与主动张力,将计算时间从数小时缩短至秒级。基于所得参数,实现整个心动周期的FE建模,速度提升75倍。在运动约束下,模型更准确匹配影像位移,平均Dice从0.849提升至0.927,同时保持真实的压容关系。该方法通过反推材料参数与提升运动保真度,优于以往PINN-FE模型。仅用单个受试者运动数据重建形状模态,避免依赖大规模数据集,增强患者特异性。IMC-PINN-FE为快速、个性化、图像一致的心脏生物力学建模提供了高效可靠方案。
原文摘要 · Abstract (English)
Elucidating the biomechanical behavior of the myocardium is crucial for understanding cardiac physiology, but cannot be directly inferred from clinical imaging and typically requires finite element (FE) simulations. However, conventional FE methods are computationally expensive and often fail to reproduce observed cardiac motions. We propose IMC-PINN-FE, a physics-informed neural network (PINN) framework that integrates imaged motion consistency (IMC) with FE modeling for patient-specific left ventricular (LV) biomechanics. Cardiac motion is first estimated from MRI or echocardiography using either a pre-trained attention-based network or an unsupervised cyclic-regularized network, followed by extraction of motion modes. IMC-PINN-FE then rapidly estimates myocardial stiffness and active tension by fitting clinical pressure measurements, accelerating computation from hours to seconds compared to traditional inverse FE. Based on these parameters, it performs FE modeling across the cardiac cycle at 75x speedup. Through motion constraints, it matches imaged displacements more accurately, improving average Dice from 0.849 to 0.927, while preserving realistic pressure-volume behavior. IMC-PINN-FE advances previous PINN-FE models by introducing back-computation of material properties and better motion fidelity. Using motion from a single subject to reconstruct shape modes also avoids the need for large datasets and improves patient specificity. IMC-PINN-FE offers a robust and efficient approach for rapid, personalized, and image-consistent cardiac biomechanical modeling.
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