将3D超声融入肝肿瘤消融治疗，解决图像配准难题。
A Novel Framework for Integrating 3D Ultrasound into Percutaneous Liver Tumour Ablation
- 用3D超声作中间桥梁，简化2D超声与CT/MRI配准流程。
- 配准误差仅2-4毫米，单对图像处理耗时0.22秒。
- 非刚性配准使平均误差降低40%，适合临床实时应用。
3D超声成像在经皮肝肿瘤消融中展现出显著优势，其临床整合对推动3D超声进入治疗领域至关重要。然而，超声图像中肿瘤识别困难仍是阻碍其广泛应用的主要挑战。本文提出一种新型框架，将3D超声无缝集成到标准消融流程中。核心是提出一种临床可行的2D超声-CT/MRI配准方法，利用3D超声作为中间媒介，降低配准复杂度。为高效验证配准流程，还设计了一种直观的多模态图像可视化技术。研究结果显示，2D超声-CT/MRI配准的标志点误差约为2-4毫米，单对图像处理时间仅0.22秒。非刚性配准相比刚性配准将平均对齐误差降低了约40%。结果证明了所提2D超声-CT/MRI配准流程的有效性。该集成框架显著提升了3D超声在经皮肿瘤消融中的能力，展示了其拓展治疗作用的临床潜力。
原文摘要 · Abstract (English)
3D ultrasound (US) imaging has shown significant benefits in enhancing the outcomes of percutaneous liver tumour ablation. Its clinical integration is crucial for transitioning 3D US into the therapeutic domain. However, challenges of tumour identification in US images continue to hinder its broader adoption. In this work, we propose a novel framework for integrating 3D US into the standard ablation workflow. We present a key component, a clinically viable 2D US-CT/MRI registration approach, leveraging 3D US as an intermediary to reduce registration complexity. To facilitate efficient verification of the registration workflow, we also propose an intuitive multimodal image visualization technique. In our study, 2D US-CT/MRI registration achieved a landmark distance error of approximately 2-4 mm with a runtime of 0.22s per image pair. Additionally, non-rigid registration reduced the mean alignment error by approximately 40% compared to rigid registration. Results demonstrated the efficacy of the proposed 2D US-CT/MRI registration workflow. Our integration framework advanced the capabilities of 3D US imaging in improving percutaneous tumour ablation, demonstrating the potential to expand the therapeutic role of 3D US in clinical interventions.
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