3D打印翻滚微机器人，磁控靶向送药，体内测试有效
Novel Design of 3D Printed Tumbling Microrobots for in vivo Targeted Drug Delivery
- 用光固化3D打印+永磁体，磁驱动实现翻滚运动
- 在干/湿环境、温变下均稳定运行，药物释放可控
- 动物实验验证安全有效，适合大肠靶向给药
本文提出一种新型3D打印翻滚微机器人设计，专用于体内靶向药物递送。采用立体光刻3D打印技术制造，集成永磁微元件，通过旋转磁场驱动系统实现操控。实验涵盖多种几何结构、驱动频率及环境条件（干/湿、温度变化）下的运动性能测试。提出三种药物装载方案，并利用聚焦超声系统评估热触发药物释放行为，同时开展生物相容性测试。动物模型实验包括组织模拟物和大鼠体内测试，全面评估性能与兼容性。结果表明所提设计具备优异鲁棒性与适应性，展现出高效、精准的体内药物递送潜力。该方法解决了现有翻滚微机器人设计的局限性，为大肠靶向给药提供了新路径。
原文摘要 · Abstract (English)
This paper presents innovative designs for 3D-printed tumbling microrobots, specifically engineered for targeted in vivo drug delivery applications. The microrobot designs, created using stereolithography 3D printing technologies, incorporate permanent micro-magnets to enable actuation via a rotating magnetic field actuator system. The experimental framework encompasses a series of locomotion characterization tests to evaluate microrobot performance under various conditions. Testing variables include variations in microrobot geometries, actuation frequencies, and environmental conditions, such as dry and wet environments, and temperature changes. The paper outlines designs for three drug loading methods, along with comprehensive assessments thermal drug release using a focused ultrasound system, as well as biocompatibility tests. Animal model testing involves tissue phantoms and in vivo rat models, ensuring a thorough evaluation of the microrobots' performance and compatibility. The results highlight the robustness and adaptability of the proposed microrobot designs, showcasing the potential for efficient and targeted in vivo drug delivery. This novel approach addresses current limitations in existing tumbling microrobot designs and paves the way for advancements in targeted drug delivery within the large intestine.
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