用AI自主设计并执行生物实验,提升实验一致性与可扩展性。
BioMARS: A Multi-Agent Robotic System for Autonomous Biological Experiments
- 分层Agent架构:科学家、技师、质检员协同完成实验全流程。
- 自动传代培养效果媲美人工,细胞存活率与形态保持更稳定。
- 支持实时人机协作,适配多种实验室设备,适合自动化研究者。
大型语言模型(LLMs)和视觉-语言模型(VLMs)有望推动生物研究的自动化实验。然而,其应用受限于固定流程设计、对动态实验环境适应性差、错误处理不足以及操作复杂。本文提出BioMARS(Biological Multi-Agent Robotic System),一个集成LLMs、VLMs与模块化机器人的智能平台,可自主设计、规划并执行生物实验。系统采用分层架构:科学家代理通过检索增强生成合成实验协议;技师代理将其转化为可执行的机器人伪代码;质检代理则通过多模态感知与异常检测保障流程完整性。该系统能自主完成细胞传代与培养任务,在细胞活力、一致性和形态完整性方面达到或超过人工水平。同时支持上下文感知优化,在区分视网膜色素上皮细胞方面优于传统策略。提供网页界面实现人机实时协作,模块化后端可扩展集成实验室硬件。结果表明,通用化的AI驱动实验自动化具备可行性,语言模型推理在生物研究中具有变革潜力。
原文摘要 · Abstract (English)
Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited adaptability to dynamic lab conditions, inadequate error handling, and high operational complexity. Here we introduce BioMARS (Biological Multi-Agent Robotic System), an intelligent platform that integrates LLMs, VLMs, and modular robotics to autonomously design, plan, and execute biological experiments. BioMARS uses a hierarchical architecture: the Biologist Agent synthesizes protocols via retrieval-augmented generation; the Technician Agent translates them into executable robotic pseudo-code; and the Inspector Agent ensures procedural integrity through multimodal perception and anomaly detection. The system autonomously conducts cell passaging and culture tasks, matching or exceeding manual performance in viability, consistency, and morphological integrity. It also supports context-aware optimization, outperforming conventional strategies in differentiating retinal pigment epithelial cells. A web interface enables real-time human-AI collaboration, while a modular backend allows scalable integration with laboratory hardware. These results highlight the feasibility of generalizable, AI-driven laboratory automation and the transformative role of language-based reasoning in biological research.
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