arXiv:2507.02064q-bio.NCcs.AI2025-07被引 5

提出大脑导航的记忆重构机制,让回忆能引导路线规划。

REMI: Reconstructing Episodic Memory During Internally Driven Path Planning

  • 用自关联机制连接位置细胞与网格细胞,实现感官线索触发目标定位
  • 模拟显示网格基规划可走捷径并推广局部路径至远距离
  • 适合神经科学、类脑智能研究者阅读

内嗅皮层(MEC)的网格细胞与海马体(HC)的位置细胞共同构成空间表征:前者呈三角网格放电模式,后者在特定位置激活并响应情境线索。二者如何协同支持空间编码与内在驱动的路径规划(如由线索回忆目的地后导航)?本文提出一种系统级理论,阐明网格细胞与位置细胞的连接机制如何实现线索触发的目标检索、路径规划及沿规划路线的感官体验重建。我们提出位置细胞将感官输入与网格细胞模式自关联,使感官线索可触发目标位置的网格模式回忆。理论分析表明,基于网格的规划可实现未访问区域间的捷径,并将局部转移泛化为长程路径。规划过程中,中间网格状态激活位置细胞模式补全,重构沿途感官体验。通过单层循环神经网络建模海马-内嗅环路及规划子网络,在生物合理导航模拟(RatatouGym)和视觉真实任务(Habitat Sim)中均验证了上述效果。

原文摘要 · Abstract (English)

Grid cells in the medial entorhinal cortex (MEC) and place cells in the hippocampus (HC) both form spatial representations. Grid cells fire in triangular grid patterns, while place cells fire at specific locations and respond to contextual cues. How do these interacting systems support not only spatial encoding but also internally driven path planning, such as navigating to locations recalled from cues? Here, we propose a system-level theory of MEC-HC wiring that explains how grid and place cell patterns could be connected to enable cue-triggered goal retrieval, path planning, and reconstruction of sensory experience along planned routes. We suggest that place cells autoassociate sensory inputs with grid cell patterns, allowing sensory cues to trigger recall of goal-location grid patterns. We show analytically that grid-based planning permits shortcuts through unvisited locations and generalizes local transitions to long-range paths. During planning, intermediate grid states trigger place cell pattern completion, reconstructing sensory experiences along the route. Using a single-layer RNN modeling the HC-MEC loop with a planning subnetwork, we demonstrate these effects in both biologically grounded navigation simulations using RatatouGym and visually realistic navigation tasks using Habitat Sim.

神经机制路径规划记忆重构

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