仅用快速无造影的心脏磁共振影像,就能精准分割心肌梗死的瘢痕和水肿。
CineMyoPS: Segmenting Myocardial Pathologies from Cine Cardiac MR
- 通过联合学习运动与解剖特征,构建端到端分割网络
- 在多中心数据集上实现媲美多序列成像的分割精度
- 适合临床快速评估心梗患者,尤其缺造影条件时
心肌梗死是全球主要致死病因之一。延迟钆增强(LGE)和T2加权心脏磁共振(CMR)可分别识别心肌瘢痕与水肿,对风险分层和预后评估至关重要。尽管多序列联合信息有益,但获取这些序列耗时且受限于造影剂使用。动态电影型CMR是一种快速、无造影的成像技术,能同时显示心肌运动与结构异常,反映急性心梗变化。为此,我们提出一种名为CineMyoPS的端到端深度神经网络,仅依赖电影型CMR图像完成心肌病灶(即瘢痕与水肿)分割。该模型提取与心梗相关的运动与解剖特征,并设计一致性损失(类比协同训练策略)以促进两者联合学习;进一步提出时序聚合策略,整合心脏周期中病灶相关特征,提升分割准确性。在多中心数据集上的实验表明,CineMyoPS在心肌病灶分割、运动估计与解剖分割任务中均表现优异。
原文摘要 · Abstract (English)
Myocardial infarction (MI) is a leading cause of death worldwide. Late gadolinium enhancement (LGE) and T2-weighted cardiac magnetic resonance (CMR) imaging can respectively identify scarring and edema areas, both of which are essential for MI risk stratification and prognosis assessment. Although combining complementary information from multi-sequence CMR is useful, acquiring these sequences can be time-consuming and prohibitive, e.g., due to the administration of contrast agents. Cine CMR is a rapid and contrast-free imaging technique that can visualize both motion and structural abnormalities of the myocardium induced by acute MI. Therefore, we present a new end-to-end deep neural network, referred to as CineMyoPS, to segment myocardial pathologies, \ie scars and edema, solely from cine CMR images. Specifically, CineMyoPS extracts both motion and anatomy features associated with MI. Given the interdependence between these features, we design a consistency loss (resembling the co-training strategy) to facilitate their joint learning. Furthermore, we propose a time-series aggregation strategy to integrate MI-related features across the cardiac cycle, thereby enhancing segmentation accuracy for myocardial pathologies. Experimental results on a multi-center dataset demonstrate that CineMyoPS achieves promising performance in myocardial pathology segmentation, motion estimation, and anatomy segmentation.
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