无需扫描即可实现厘米级大视野亚微米成像，突破显微镜视野与分辨率的瓶颈。
Curvature-adaptive gigapixel microscopy at submicron resolution and centimeter scale
- 采用自适应调焦微相机阵列与远心光刻镜头，实现单次成像
- 16.3×18.8 mm²视野下达0.84 μm分辨率，无机械扫描
- 适合生物、材料等大尺度不平整样本的多模态高通量成像
厘米级大视野亚微米分辨率显微成像受限于视野、分辨率与速度之间的权衡。样品在厘米尺度上通常不平整，现有方案常需机械扫描以保证聚焦，导致成像速度下降。本文提出PANORAMA，一种单次曝光、重成像显微镜，在16.3×18.8 mm²视野内实现0.84 μm分辨率，无需机械扫描。通过远心光刻镜头、大口径管镜及自适应调焦微相机阵列，PANORAMA可在平坦、弯曲或不规则样本上保持亚微米聚焦。该方法显著提升成像通量与适应性，实现大尺度非平面样本的一次性吉像素多模态成像，拓展其在生物医学与材料成像中的应用。
原文摘要 · Abstract (English)
Large-area microscopy with submicron resolution is limited by tradeoffs between field of view (FOV), resolution, and imaging speed. Samples are rarely flat across centimeter-scale FOV, which often requires existing solutions to use mechanical scanning to ensure focused capture at reduced throughput. Here, we present PANORAMA, a single-shot, re-imaging microscope that achieves seamless, gigapixel imaging over a 16.3$\times$18.8 $\text{mm}^2$ FOV at 0.84 um resolution without mechanical scanning. By using a telecentric photolithography lens, a large-aperture tube lens, and a flat micro-camera array with adaptive per-camera focus control, PANORAMA maintains submicron focus across flat, curved or uneven samples that span centimeters. This approach improves imaging throughput and adaptability, enabling gigapixel multi-modal microscopy of large flat and non-flat samples in one shot, thus broadening its applications in biomedical and materials imaging.
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