用图神经网络分析失眠患者脑电数据,识别关键脑区异常
Graph Convolutional Neural Networks to Model the Brain for Insomnia
- 构建脑电通道功能连接图,用GCNN捕捉失眠相关特征
- 50秒滑动窗口下分类准确率达70%(窗口级)和68%(个体级)
- 颞顶区电极缺失影响最大,与已知失眠脑区异常吻合
失眠影响全球大量人群,现有治疗常伴头痛、头晕等副作用,亟需改进。脑网络建模在阿尔茨海默病、癫痫等疾病中已助力临床决策,但尚未用于失眠。本研究利用连续长时脑电数据,基于电极间功能连接与空间距离构建脑网络,计算各主要脑电波段的功率谱密度,训练图卷积神经网络(GCNN)进行失眠分类。结果表明,50秒非重叠滑动窗口为最优分割策略,在窗口级别达到70%分类准确率,个体级别达68%。移除位于枕顶区的电极C4-P4、F4-C4和C4-A1导致模型性能下降最显著,这些区域与失眠患者功能连接异常的已知脑区位置一致,支持结果可靠性。
原文摘要 · Abstract (English)
Insomnia affects a vast population of the world and can have a wide range of causes. Existing treatments for insomnia have been linked with many side effects like headaches, dizziness, etc. As such, there is a clear need for improved insomnia treatment. Brain modelling has helped with assessing the effects of brain pathology on brain network dynamics and with supporting clinical decisions in the treatment of Alzheimer's disease, epilepsy, etc. However, such models have not been developed for insomnia. Therefore, this project attempts to understand the characteristics of the brain of individuals experiencing insomnia using continuous long-duration EEG data. Brain networks are derived based on functional connectivity and spatial distance between EEG channels. The power spectral density of the channels is then computed for the major brain wave frequency bands. A graph convolutional neural network (GCNN) model is then trained to capture the functional characteristics associated with insomnia and configured for the classification task to judge performance. Results indicated a 50-second non-overlapping sliding window was the most suitable choice for EEG segmentation. This approach achieved a classification accuracy of 70% at window level and 68% at subject level. Additionally, the omission of EEG channels C4-P4, F4-C4 and C4-A1 caused higher degradation in model performance than the removal of other channels. These channel electrodes are positioned near brain regions known to exhibit atypical levels of functional connectivity in individuals with insomnia, which can explain such results.
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