用自监督方法优化老式脑电检测,提升癫痫定位精度。
Self-Supervised Distillation of Legacy Rule-Based Methods for Enhanced EEG-Based Decision-Making
- 用变分自编码器学习脑电信号特征,聚类生成弱标签。
- 在多中心数据上比现有方法减少误报,准确率显著提升。
- 无需大量人工标注,适合临床快速部署使用。
颅内脑电图(iEEG)中的高频振荡(HFOs)是定位癫痫致痫灶的关键生物标志物。传统基于规则的检测方法虽能捕捉临床相关信号,但误报率高,需耗时的人工复核。监督学习方法虽可分类检测结果,却依赖难获取的标注数据,且因标注者间一致性差、缺乏病理标准,难以实现精准标注。本文提出自监督标签发现(SS2LD)框架,利用遗留检测器产生的大量候选事件,通过变分自编码器(VAE)进行形态学预训练,学习有意义的潜在表示,并聚类生成弱监督信号以识别病理性事件。再用该信号训练分类器,结合真实与VAE增强数据优化检测边界。在大规模多中心间期iEEG数据集上评估,SS2LD性能优于当前最优方法。该方法具备可扩展性、低标注依赖性和临床有效性,为利用旧检测工具精准识别病理性HFO提供了新路径。
原文摘要 · Abstract (English)
High-frequency oscillations (HFOs) in intracranial Electroencephalography (iEEG) are critical biomarkers for localizing the epileptogenic zone in epilepsy treatment. However, traditional rule-based detectors for HFOs suffer from unsatisfactory precision, producing false positives that require time-consuming manual review. Supervised machine learning approaches have been used to classify the detection results, yet they typically depend on labeled datasets, which are difficult to acquire due to the need for specialized expertise. Moreover, accurate labeling of HFOs is challenging due to low inter-rater reliability and inconsistent annotation practices across institutions. The lack of a clear consensus on what constitutes a pathological HFO further challenges supervised refinement approaches. To address this, we leverage the insight that legacy detectors reliably capture clinically relevant signals despite their relatively high false positive rates. We thus propose the Self-Supervised to Label Discovery (SS2LD) framework to refine the large set of candidate events generated by legacy detectors into a precise set of pathological HFOs. SS2LD employs a variational autoencoder (VAE) for morphological pre-training to learn meaningful latent representation of the detected events. These representations are clustered to derive weak supervision for pathological events. A classifier then uses this supervision to refine detection boundaries, trained on real and VAE-augmented data. Evaluated on large multi-institutional interictal iEEG datasets, SS2LD outperforms state-of-the-art methods. SS2LD offers a scalable, label-efficient, and clinically effective strategy to identify pathological HFOs using legacy detectors.
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