arXiv:2507.15340eess.IVcs.AI2025-07

用Transformer提升低剂量肺CT分辨率,助力精准诊断与预后

MedSR-Impact: Transformer-Based Super-Resolution for Lung CT Segmentation, Radiomics, Classification, and Prognosis

  • 基于Transformer设计可扩展的超分辨率网络,重建低剂量CT细节
  • 分割准确率提升4%(Dice),放射组学特征更稳定,预后预测性能提高
  • 适合临床部署,兼容多种扫描设备,降低辐射风险

高分辨率胸腔CT对精准诊疗至关重要,但受限于辐射剂量和硬件成本。本文提出Transformer体积超分辨率网络(TVSRN-V2),一种面向临床实用的肺CT分析超分辨率框架。模型采用可扩展组件,包括跨平面注意力模块(TAB)和Swin Transformer V2,能有效重建低剂量CT中的精细解剖结构,并无缝集成到下游分析流程中。在多个临床队列上评估其在肺段分割、放射组学和预后预测三项关键任务上的表现。为增强对不同扫描协议的鲁棒性,引入伪低分辨率数据增强,模拟设备多样性且无需私有数据。结果表明,TVSRN-V2显著提升分割精度(Dice+4%)、放射组学特征重现性,并改善预测性能(C-index+0.06,AUC提升)。这些成果证明,通过超分辨率恢复结构细节可显著提升临床决策支持能力,使TVSRN-V2成为一种工程完善、临床可行的低剂量成像与定量分析系统。

原文摘要 · Abstract (English)

High-resolution volumetric computed tomography (CT) is essential for accurate diagnosis and treatment planning in thoracic diseases; however, it is limited by radiation dose and hardware costs. We present the Transformer Volumetric Super-Resolution Network (\textbf{TVSRN-V2}), a transformer-based super-resolution (SR) framework designed for practical deployment in clinical lung CT analysis. Built from scalable components, including Through-Plane Attention Blocks (TAB) and Swin Transformer V2 -- our model effectively reconstructs fine anatomical details in low-dose CT volumes and integrates seamlessly with downstream analysis pipelines. We evaluate its effectiveness on three critical lung cancer tasks -- lobe segmentation, radiomics, and prognosis -- across multiple clinical cohorts. To enhance robustness across variable acquisition protocols, we introduce pseudo-low-resolution augmentation, simulating scanner diversity without requiring private data. TVSRN-V2 demonstrates a significant improvement in segmentation accuracy (+4\% Dice), higher radiomic feature reproducibility, and enhanced predictive performance (+0.06 C-index and AUC). These results indicate that SR-driven recovery of structural detail significantly enhances clinical decision support, positioning TVSRN-V2 as a well-engineered, clinically viable system for dose-efficient imaging and quantitative analysis in real-world CT workflows.

超分辨率肺CTTransformer临床应用

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