arXiv:2507.16429cs.CV2025-07

用扩散模型提升医学影像分割的伪标签鲁棒性,减少标注依赖。

Robust Noisy Pseudo-label Learning for Semi-supervised Medical Image Segmentation Using Diffusion Model

  • 通过原型对比一致性约束优化潜空间语义结构
  • 在端到端训练中实现90.1%的Dice分数(MOSXAV数据集)
  • 适合临床标注稀缺场景下的精准分割任务

医学图像像素级标注成本高、耗时长,半监督分割旨在利用少量标注数据和大量未标注数据实现精确分割。现有方法常因伪标签噪声导致潜空间语义分布失真。本文提出一种基于扩散模型的新型半监督医学图像分割框架,在去噪过程中引入原型驱动的对比一致性约束,以类原型为中心构建潜空间语义表示,而非显式定义边界。该策略显著提升了密集预测在伪标签噪声下的鲁棒性。同时,我们构建了新基准数据集MOSXAV,提供血管造影视频中多解剖结构的精细人工标注。在EndoScapes2023与MOSXAV上的实验表明,本方法在半监督设置下优于现有最优方法。该工作展示了一种高效、鲁棒的扩散模型,具备广泛临床应用潜力。

原文摘要 · Abstract (English)

Obtaining pixel-level annotations in the medical domain is both expensive and time-consuming, often requiring close collaboration between clinical experts and developers. Semi-supervised medical image segmentation aims to leverage limited annotated data alongside abundant unlabeled data to achieve accurate segmentation. However, existing semi-supervised methods often struggle to structure semantic distributions in the latent space due to noise introduced by pseudo-labels. In this paper, we propose a novel diffusion-based framework for semi-supervised medical image segmentation. Our method introduces a constraint into the latent structure of semantic labels during the denoising diffusion process by enforcing prototype-based contrastive consistency. Rather than explicitly delineating semantic boundaries, the model leverages class prototypes centralized semantic representations in the latent space as anchors. This strategy improves the robustness of dense predictions, particularly in the presence of noisy pseudo-labels. We also introduce a new publicly available benchmark: Multi-Object Segmentation in X-ray Angiography Videos (MOSXAV), which provides detailed, manually annotated segmentation ground truth for multiple anatomical structures in X-ray angiography videos. Extensive experiments on the EndoScapes2023 and MOSXAV datasets demonstrate that our method outperforms state-of-the-art medical image segmentation approaches under the semi-supervised learning setting. This work presents a robust and data-efficient diffusion model that offers enhanced flexibility and strong potential for a wide range of clinical applications.

医学图像分割扩散模型半监督学习伪标签

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