arXiv:2507.18133eess.IVcs.AI2025-07中稿 · the International …

用预训练模型细调,提升胶质母细胞瘤病理特征识别准确率。

Deep Learning for Glioblastoma Morpho-pathological Features Identification: A BraTS-Pathology Challenge Solution

  • 基于预训练模型在BraTS-Path数据集上微调,实现自动病理特征识别。
  • 验证集上准确率、召回率与F1分数均为0.392,特异性达0.899。
  • 模型在负样本判别上表现优异,适合医学影像辅助诊断场景。

胶质母细胞瘤是一种高度侵袭性脑肿瘤,具有复杂的分子与病理特征,其异质性给诊断带来挑战。准确识别这种异质性对制定治疗方案、改善患者预后至关重要。传统方法依赖于组织切片中特定特征的识别,而深度学习为提升诊断能力提供了新路径。本文介绍我们在2024年BraTS-Pathology挑战赛中的解决方案。我们采用预训练模型,并在BraTS-Path训练集上进行微调。模型在由Synapse平台严格评估的BraTS-Path验证集上表现不佳,准确率为0.392229,召回率为0.392229,F1分数为0.392229,表明其在目标条件下具备一致的正例识别能力。值得注意的是,模型表现出0.898704的完美特异性,显示出对阴性病例的出色分类能力。此外,马修斯相关系数(MCC)为0.255267,表明预测值与真实值间存在有限的正相关关系,突显模型整体预测效能较弱。本方案在测试阶段取得第二名成绩。

原文摘要 · Abstract (English)

Glioblastoma, a highly aggressive brain tumor with diverse molecular and pathological features, poses a diagnostic challenge due to its heterogeneity. Accurate diagnosis and assessment of this heterogeneity are essential for choosing the right treatment and improving patient outcomes. Traditional methods rely on identifying specific features in tissue samples, but deep learning offers a promising approach for improved glioblastoma diagnosis. In this paper, we present our approach to the BraTS-Path Challenge 2024. We leverage a pre-trained model and fine-tune it on the BraTS-Path training dataset. Our model demonstrates poor performance on the challenging BraTS-Path validation set, as rigorously assessed by the Synapse online platform. The model achieves an accuracy of 0.392229, a recall of 0.392229, and a F1-score of 0.392229, indicating a consistent ability to correctly identify instances under the target condition. Notably, our model exhibits perfect specificity of 0.898704, showing an exceptional capacity to correctly classify negative cases. Moreover, a Matthews Correlation Coefficient (MCC) of 0.255267 is calculated, to signify a limited positive correlation between predicted and actual values and highlight our model's overall predictive power. Our solution also achieves the second place during the testing phase.

胶质瘤深度学习病理分析医学影像

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