改进针状物重建后处理,显著降低医学影像中的定位误差。
Dealing with Segmentation Errors in Needle Reconstruction for MRI-Guided Brachytherapy
- 针对分割错误设计鲁棒性后处理方法
- 针尖与针底定位误差中位数分别低至1.07和0.43毫米
- 适用于前列腺癌微创放疗,适合临床精准导航
植入式针状放射源用于近距离放疗,图像引导计划需精确重建针体。人工标注耗时费力,自动重建常采用两阶段流程:先分割后后处理。尽管深度学习在分割上有效,但结果仍含误差,现有后处理方法对各类错误不鲁棒。为此,本文提出针对分割错误的后处理改进方案,显著提升重建精度。在基于专业医生标注的前列腺癌MRI数据集上测试,261根针的实验显示,最优方法实现针尖定位误差中位数1.07毫米(IQR ±1.04),针底误差0.43毫米(IQR ±0.46),针身误差0.75毫米(IQR ±0.69),且无假阳性或假阴性针体漏检。
原文摘要 · Abstract (English)
Brachytherapy involves bringing a radioactive source near tumor tissue using implanted needles. Image-guided brachytherapy planning requires amongst others, the reconstruction of the needles. Manually annotating these needles on patient images can be a challenging and time-consuming task for medical professionals. For automatic needle reconstruction, a two-stage pipeline is commonly adopted, comprising a segmentation stage followed by a post-processing stage. While deep learning models are effective for segmentation, their results often contain errors. No currently existing post-processing technique is robust to all possible segmentation errors. We therefore propose adaptations to existing post-processing techniques mainly aimed at dealing with segmentation errors and thereby improving the reconstruction accuracy. Experiments on a prostate cancer dataset, based on MRI scans annotated by medical professionals, demonstrate that our proposed adaptations can help to effectively manage segmentation errors, with the best adapted post-processing technique achieving median needle-tip and needle-bottom point localization errors of $1.07$ (IQR $\pm 1.04$) mm and $0.43$ (IQR $\pm 0.46$) mm, respectively, and median shaft error of $0.75$ (IQR $\pm 0.69$) mm with 0 false positive and 0 false negative needles on a test set of 261 needles.
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