arXiv:2507.19547cs.LGcs.CY2025-07

用深度学习自动分析心内电图,帮医生找房颤的病灶。

Latent Representations of Intracardiac Electrograms for Atrial Fibrillation Driver Detection

  • 用卷积自编码器无监督提取心内电图的潜在特征。
  • 检测心房电活动纠缠的AUC达0.93,旋转/局灶活动达0.73-0.76。
  • 可实时运行,适合植入临床电生理标测系统。

房颤是最常见的持续性心律失常,但现有消融治疗(如肺静脉隔离)在持续性房颤中常无效,因非肺静脉驱动灶参与其中。本研究提出一种基于卷积自编码器的深度学习框架,用于从消融术中记录的单极和双极心内电图(EGMs)中进行无监督特征提取。这些潜在表示能表征心房电活动,实现电图分析自动化,辅助房颤驱动灶检测。数据集包含291名患者共11,404次采集,含228,080条单极和171,060条双极电图。自编码器成功学习出低重建误差的潜在表示,保留了波形形态特征。提取的嵌入向量使下游分类器对旋转和局灶活动检测达到中等性能(AUC 0.73–0.76),对心房电图纠缠识别表现优异(AUC 0.93)。该方法可实时运行,可集成至临床电生理标测系统,辅助消融过程中识别致心律失常区域。研究展示了无监督学习从心内信号中挖掘生理有意义特征的潜力。

原文摘要 · Abstract (English)

Atrial Fibrillation (AF) is the most prevalent sustained arrhythmia, yet current ablation therapies, including pulmonary vein isolation, are frequently ineffective in persistent AF due to the involvement of non-pulmonary vein drivers. This study proposes a deep learning framework using convolutional autoencoders for unsupervised feature extraction from unipolar and bipolar intracavitary electrograms (EGMs) recorded during AF in ablation studies. These latent representations of atrial electrical activity enable the characterization and automation of EGM analysis, facilitating the detection of AF drivers. The database consisted of 11,404 acquisitions recorded from 291 patients, containing 228,080 unipolar EGMs and 171,060 bipolar EGMs. The autoencoders successfully learned latent representations with low reconstruction loss, preserving the morphological features. The extracted embeddings allowed downstream classifiers to detect rotational and focal activity with moderate performance (AUC 0.73-0.76) and achieved high discriminative performance in identifying atrial EGM entanglement (AUC 0.93). The proposed method can operate in real-time and enables integration into clinical electroanatomical mapping systems to assist in identifying arrhythmogenic regions during ablation procedures. This work highlights the potential of unsupervised learning to uncover physiologically meaningful features from intracardiac signals.

房颤电图分析深度学习自编码器

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