arXiv:2507.19566eess.IV2025-07

用改进的CNN模型自动识别大鼠发情周期,准确率达96.31%。

SLENet: A Novel Multiscale CNN-Based Network for Detecting the Rats Estrous Cycle

  • 基于EfficientNet改进,引入空间注意力与非局部机制增强特征提取
  • 在2655张阴道细胞图像上达到96.31%准确率,优于基准模型
  • 适合生殖与药理研究中需精准判断发情周期的实验设计

在临床医学中,大鼠常被用作实验动物,其发情周期显著影响生物反应,导致实验结果差异。因此,准确判断发情周期对减少干扰至关重要。手动识别存在成本高、训练周期长、主观性强等问题。本文提出一种基于EfficientNet的新型分类网络——空间长距离高效网络(SLENet),通过引入新型空间高效通道注意力(SECA)机制替代原挤压激励模块,并在最后一层卷积后加入非局部注意力机制,以增强长程依赖捕捉能力。实验使用2,655张大鼠阴道上皮细胞显微图像,测试集包含531张图像。结果表明,SLENet准确率达96.31%,优于基准EfficientNet模型(94.2%)。该成果为生殖与药理等基于大鼠的研究优化实验设计提供了实用价值,但当前仅基于显微图像数据,未考虑时间序列等多模态信息,未来需融合多源输入。

原文摘要 · Abstract (English)

In clinical medicine, rats are commonly used as experimental subjects. However, their estrous cycle significantly impacts their biological responses, leading to differences in experimental results. Therefore, accurately determining the estrous cycle is crucial for minimizing interference. Manually identifying the estrous cycle in rats presents several challenges, including high costs, long training periods, and subjectivity. To address these issues, this paper proposes a classification network-Spatial Long-distance EfficientNet (SLENet). This network is designed based on EfficientNet, specifically modifying the Mobile Inverted Bottleneck Convolution (MBConv) module by introducing a novel Spatial Efficient Channel Attention (SECA) mechanism to replace the original Squeeze Excitation (SE) module. Additionally, a Non-local attention mechanism is incorporated after the last convolutional layer to enhance the network's ability to capture long-range dependencies. The dataset used 2,655 microscopic images of rat vaginal epithelial cells, with 531 images in the test set. Experimental results indicate that SLENet achieved an accuracy of 96.31%, outperforming baseline EfficientNet model (94.2%). This finding provide practical value for optimizing experimental design in rat-based studies such as reproductive and pharmacological research, but this study is limited to microscopy image data, without considering other factors like temporal patterns, thus, incorporating multi-modal input is necessary for future application.

图像分类生物医学注意力机制大鼠研究

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