用多个AI科学家协作分析基因数据,既可靠又灵活。
GenoMAS: A Multi-Agent Framework for Scientific Discovery via Code-Driven Gene Expression Analysis
- 六位AI专家通过代码协作,动态调整分析流程。
- 预处理准确率达89.13%,基因识别F1值60.48%,均超前人方法。
- 适合生物信息学研究者与自动化分析需求者使用。
基因表达分析是诸多生物医学发现的关键,但从原始转录组数据中提取洞察仍面临挑战,因涉及大量半结构化文件且需深厚领域知识。现有自动化方法或受限于僵化工作流,或因完全自主而缺乏科学严谨性。GenoMAS提出一种基于LLM的多智能体框架,将结构化工作流的可靠性与自主代理的灵活性结合。该框架通过类型化消息传递协议协调六个专用LLM智能体,共同完成分析任务。核心为引导式规划机制:编程智能体将高层任务指南分解为动作单元,并在每一步选择推进、修正、跳过或回溯,以保持逻辑连贯性并适应基因数据的特殊性。在GenoTEX基准上,GenoMAS在数据预处理上的综合相似度相关性达89.13%,基因识别的F₁值为60.48%,分别优于最优先前方法10.61%和16.85%。此外,该系统能发现文献支持的基因-表型关联,并有效控制潜在混杂因素。代码已公开于https://github.com/Liu-Hy/GenoMAS。
原文摘要 · Abstract (English)
Gene expression analysis holds the key to many biomedical discoveries, yet extracting insights from raw transcriptomic data remains formidable due to the complexity of multiple large, semi-structured files and the need for extensive domain expertise. Current automation approaches are often limited by either inflexible workflows that break down in edge cases or by fully autonomous agents that lack the necessary precision for rigorous scientific inquiry. GenoMAS charts a different course by presenting a team of LLM-based scientists that integrates the reliability of structured workflows with the adaptability of autonomous agents. GenoMAS orchestrates six specialized LLM agents through typed message-passing protocols, each contributing complementary strengths to a shared analytic canvas. At the heart of GenoMAS lies a guided-planning framework: programming agents unfold high-level task guidelines into Action Units and, at each juncture, elect to advance, revise, bypass, or backtrack, thereby maintaining logical coherence while bending gracefully to the idiosyncrasies of genomic data. On the GenoTEX benchmark, GenoMAS reaches a Composite Similarity Correlation of 89.13% for data preprocessing and an F$_1$ of 60.48% for gene identification, surpassing the best prior art by 10.61% and 16.85% respectively. Beyond metrics, GenoMAS surfaces biologically plausible gene-phenotype associations corroborated by the literature, all while adjusting for latent confounders. Code is available at https://github.com/Liu-Hy/GenoMAS.
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