arXiv:2508.02258cs.CV2025-08AAAI被引 15

用强化学习构建多模态病理检索增强生成系统,提升诊断准确性。

Patho-AgenticRAG: Towards Multimodal Agentic Retrieval-Augmented Generation for Pathology VLMs via Reinforcement Learning

  • 基于病理教材页级嵌入构建多模态数据库,支持图文联合检索。
  • 在多项病理诊断任务中显著优于现有模型,准确率提升超15%。
  • 适合需要高可信诊断支持的医学AI研发与临床辅助系统开发者。

尽管视觉语言模型(VLMs)在医学影像中展现出强大泛化能力,但病理学因图像分辨率极高、组织结构复杂及临床语义细微而面临独特挑战,导致病理VLM易产生与视觉证据不符的幻觉,削弱临床信任。现有RAG方法主要依赖文本知识库,难以利用诊断性视觉线索。为此,我们提出Patho-AgenticRAG,一种基于权威病理教材页级嵌入构建数据库的多模态RAG框架。该框架支持文本与图像联合检索,可直接获取同时包含查询文本和相关视觉线索的教材页面,避免关键图像信息丢失。此外,系统支持推理、任务分解与多轮交互搜索,在复杂诊断场景中表现更优。实验表明,Patho-AgenticRAG在多项复杂病理任务(如多选题诊断、视觉问答)中显著优于现有多模态模型。

原文摘要 · Abstract (English)

Although Vision Language Models (VLMs) have shown strong generalization in medical imaging, pathology presents unique challenges due to ultra-high resolution, complex tissue structures, and nuanced clinical semantics. These factors make pathology VLMs prone to hallucinations, i.e., generating outputs inconsistent with visual evidence, which undermines clinical trust. Existing RAG approaches in this domain largely depend on text-based knowledge bases, limiting their ability to leverage diagnostic visual cues. To address this, we propose Patho-AgenticRAG, a multimodal RAG framework with a database built on page-level embeddings from authoritative pathology textbooks. Unlike traditional text-only retrieval systems, it supports joint text-image search, enabling direct retrieval of textbook pages that contain both the queried text and relevant visual cues, thus avoiding the loss of critical image-based information. Patho-AgenticRAG also supports reasoning, task decomposition, and multi-turn search interactions, improving accuracy in complex diagnostic scenarios. Experiments show that Patho-AgenticRAG significantly outperforms existing multimodal models in complex pathology tasks like multiple-choice diagnosis and visual question answering. Our project is available at the Patho-AgenticRAG repository: https://github.com/Wenchuan-Zhang/Patho-AgenticRAG.

病理AI多模态检索生成增强强化学习

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