用咳嗽声和基础信息快速评估结核病风险,误诊率更低。
DeepGB-TB: A Risk-Balanced Cross-Attention Gradient-Boosted Convolutional Network for Rapid, Interpretable Tuberculosis Screening
- 音频与表格式数据通过双向注意力机制融合特征
- 在7国1105例数据上达成0.903的AUROC和0.851的F1分数
- 专为减少漏诊设计,适合基层医疗场景使用
大规模结核病筛查受限于传统诊断方法成本高、操作复杂。本文提出DeepGB-TB,一种仅需咳嗽音频和基础人口统计信息即可实时生成结核病风险评分的非侵入式系统。该模型将一维卷积神经网络(用于音频处理)与梯度提升决策树(用于表格特征)结合,并创新性地引入跨模态双向交叉注意力模块(CM-BCA),模拟临床医生整合症状与风险因素的推理过程。为满足临床对减少漏诊的优先要求,设计了结核病风险平衡损失函数(TRBL),对假阴性预测施加更强惩罚,显著降低高危误判。在涵盖7个国家的1,105名患者数据集上评估,达到0.903的AUROC和0.851的F1-score,刷新当前最佳水平。模型计算高效,可在普通移动设备上实现离线实时推理,适用于低资源环境。系统还可生成经临床验证的解释,增强一线医护人员信任与采纳。通过融合AI创新与公共卫生需求,DeepGB-TB为全球结核病防控提供有力工具。
原文摘要 · Abstract (English)
Large-scale tuberculosis (TB) screening is limited by the high cost and operational complexity of traditional diagnostics, creating a need for artificial-intelligence solutions. We propose DeepGB-TB, a non-invasive system that instantly assigns TB risk scores using only cough audio and basic demographic data. The model couples a lightweight one-dimensional convolutional neural network for audio processing with a gradient-boosted decision tree for tabular features. Its principal innovation is a Cross-Modal Bidirectional Cross-Attention module (CM-BCA) that iteratively exchanges salient cues between modalities, emulating the way clinicians integrate symptoms and risk factors. To meet the clinical priority of minimizing missed cases, we design a Tuberculosis Risk-Balanced Loss (TRBL) that places stronger penalties on false-negative predictions, thereby reducing high-risk misclassifications. DeepGB-TB is evaluated on a diverse dataset of 1,105 patients collected across seven countries, achieving an AUROC of 0.903 and an F1-score of 0.851, representing a new state of the art. Its computational efficiency enables real-time, offline inference directly on common mobile devices, making it ideal for low-resource settings. Importantly, the system produces clinically validated explanations that promote trust and adoption by frontline health workers. By coupling AI innovation with public-health requirements for speed, affordability, and reliability, DeepGB-TB offers a tool for advancing global TB control.
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