提出新模型与数据集,精准分割眼底血管异常区域。
Neovascularization Segmentation via a Multilateral Interaction-Enhanced Graph Convolutional Network
- 构建多任务图网络,融合病变形状与血管结构信息
- 在公开数据集上实现87.21%区域与88.12%血管的分割准确率
- 适合眼科医学影像分析与深度学习算法研究者
脉络膜新生血管(CNV)是湿性年龄相关性黄斑变性(wet AMD)的主要特征,也是全球致盲主因之一。临床中常使用光学相干断层扫描血管成像(OCTA)研究CNV病理变化,因其具备微米级分辨率且无创。因此,精准分割OCTA图像中的CNV区域与血管至关重要。然而,受限于不规则病灶形态及投影伪影、噪声和边界模糊等成像问题,分割仍具挑战。此外,公开数据集缺失也制约了分析进展。为此,本文首次构建了公开可获取的CNV数据集(CNVSeg),并提出一种新型多边交互增强图卷积网络(MTG-Net)。该网络融合区域与血管形态信息,在图域内探索语义与几何双重约束。具体由多任务框架及两个基于图的跨任务模块构成:多边交互图推理(MIGR)与多边强化图推理(MRGR)。多任务框架编码病灶形状与表面的丰富几何特征,将图像分解为三类任务特定特征图。MIGR与MRGR通过图机制迭代推理任务间的高阶关系,实现任务目标的互补优化。同时引入不确定性加权损失函数,以降低伪影与噪声对分割精度的影响。实验表明,MTG-Net优于现有方法,区域分割Dice得分为87.21%,血管分割达88.12%。
原文摘要 · Abstract (English)
Choroidal neovascularization (CNV), a primary characteristic of wet age-related macular degeneration (wet AMD), represents a leading cause of blindness worldwide. In clinical practice, optical coherence tomography angiography (OCTA) is commonly used for studying CNV-related pathological changes, due to its micron-level resolution and non-invasive nature. Thus, accurate segmentation of CNV regions and vessels in OCTA images is crucial for clinical assessment of wet AMD. However, challenges existed due to irregular CNV shapes and imaging limitations like projection artifacts, noises and boundary blurring. Moreover, the lack of publicly available datasets constraints the CNV analysis. To address these challenges, this paper constructs the first publicly accessible CNV dataset (CNVSeg), and proposes a novel multilateral graph convolutional interaction-enhanced CNV segmentation network (MTG-Net). This network integrates both region and vessel morphological information, exploring semantic and geometric duality constraints within the graph domain. Specifically, MTG-Net consists of a multi-task framework and two graph-based cross-task modules: Multilateral Interaction Graph Reasoning (MIGR) and Multilateral Reinforcement Graph Reasoning (MRGR). The multi-task framework encodes rich geometric features of lesion shapes and surfaces, decoupling the image into three task-specific feature maps. MIGR and MRGR iteratively reason about higher-order relationships across tasks through a graph mechanism, enabling complementary optimization for task-specific objectives. Additionally, an uncertainty-weighted loss is proposed to mitigate the impact of artifacts and noise on segmentation accuracy. Experimental results demonstrate that MTG-Net outperforms existing methods, achieving a Dice socre of 87.21\% for region segmentation and 88.12\% for vessel segmentation.
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