arXiv:2508.06539cs.LGmath.OC2025-08被引 1

将生存建模为生物状态空间的几何属性,无需标签即可发现预后结构。

Self-Organizing Survival Manifolds: A Theory for Unsupervised Discovery of Prognostic Structures in Biological Systems

  • 基于测地线曲率最小化构建生存能量函数,从内在生物约束中自组织出生存流形。
  • 证明在合理生物学条件下,生存对齐轨迹能自然涌现并收敛,预后与几何稳定性一致。
  • 融合热力学、熵流与黎曼曲率,为生存建模提供物理定律基础,适合跨学科研究者。

传统生存建模依赖标注结果和固定协变量,本工作提出全新视角:生存并非外部标注目标,而是生物状态空间固有曲率与流动的几何结果。我们建立自组织生存流形(SOSM)理论,生存相关动态源于由内部生物约束塑造的潜在流形上的低曲率测地线流动。引入基于测地线曲率最小化的生存能量泛函,证明其可诱导出预后与几何流动稳定性一致的结构。推导出该目标的离散与连续形式,并证明在生物合理条件下生存对齐轨迹的涌现与收敛性。框架关联热力学效率、熵流、里奇曲率与最优传输,将生存建模根植于物理定律。健康、疾病、衰老与死亡被重新诠释为流形结构的几何相变。此理论提供无标签的通用基础,弥合机器学习、生物物理学与生命几何学。

原文摘要 · Abstract (English)

Survival is traditionally modeled as a supervised learning task, reliant on curated outcome labels and fixed covariates. This work rejects that premise. It proposes that survival is not an externally annotated target but a geometric consequence: an emergent property of the curvature and flow inherent in biological state space. We develop a theory of Self-Organizing Survival Manifolds (SOSM), in which survival-relevant dynamics arise from low-curvature geodesic flows on latent manifolds shaped by internal biological constraints. A survival energy functional based on geodesic curvature minimization is introduced and shown to induce structures where prognosis aligns with geometric flow stability. We derive discrete and continuous formulations of the objective and prove theoretical results demonstrating the emergence and convergence of survival-aligned trajectories under biologically plausible conditions. The framework draws connections to thermodynamic efficiency, entropy flow, Ricci curvature, and optimal transport, grounding survival modeling in physical law. Health, disease, aging, and death are reframed as geometric phase transitions in the manifold's structure. This theory offers a universal, label-free foundation for modeling survival as a property of form, not annotation-bridging machine learning, biophysics, and the geometry of life itself.

生存分析几何学习无监督生物物理

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