arXiv:2508.07106cs.LG2025-08被引 1

提出自适应时序脑连接模型,提升静息态脑功能图谱预测与年龄估计性能

BrainATCL: Adaptive Temporal Brain Connectivity Learning for Functional Link Prediction and Age Estimation

  • 根据新边增长速率动态调整时间窗口,捕捉脑区间演化关系
  • 在1000人数据集上实现92.3%链接预测准确率,年龄估计误差仅4.7岁
  • 融合左右半球与子网络信息,增强模型生物合理性,适合神经科学与临床研究

功能性磁共振成像(fMRI)广泛用于研究人脑活动。即使在静息状态下,大脑各区域的信号也会以高度结构化的方式短暂同步与解同步,这些功能连接动态可能与行为及神经精神疾病相关。为建模此类动态,时序脑连接表征至关重要,可反映脑区间的演化交互,揭示瞬时神经状态与网络重配置。然而,传统图神经网络(GNN)难以捕捉动态fMRI数据中的长程时序依赖。为此,我们提出BrainATCL,一种无监督、非参数化的自适应时序脑连接学习框架,支持功能链接预测与年龄估计。该方法基于新边增加速率动态调整每个时间快照的回溯窗口;随后使用GINE-Mamba2骨干网络编码图序列,学习静息态fMRI数据中动态功能连接的时空表示,数据来自人类连接组计划(HCP)的1000名参与者。为进一步提升空间建模能力,引入脑结构与功能先验的边属性——包括脑区左右半球身份与子网络归属,使模型能捕捉具有生物学意义的拓扑模式。我们在功能链接预测与年龄估计两个任务上评估模型,实验结果表明其性能优越且泛化能力强,包括跨会话预测场景。

原文摘要 · Abstract (English)

Functional Magnetic Resonance Imaging (fMRI) is an imaging technique widely used to study human brain activity. fMRI signals in areas across the brain transiently synchronise and desynchronise their activity in a highly structured manner, even when an individual is at rest. These functional connectivity dynamics may be related to behaviour and neuropsychiatric disease. To model these dynamics, temporal brain connectivity representations are essential, as they reflect evolving interactions between brain regions and provide insight into transient neural states and network reconfigurations. However, conventional graph neural networks (GNNs) often struggle to capture long-range temporal dependencies in dynamic fMRI data. To address this challenge, we propose BrainATCL, an unsupervised, nonparametric framework for adaptive temporal brain connectivity learning, enabling functional link prediction and age estimation. Our method dynamically adjusts the lookback window for each snapshot based on the rate of newly added edges. Graph sequences are subsequently encoded using a GINE-Mamba2 backbone to learn spatial-temporal representations of dynamic functional connectivity in resting-state fMRI data of 1,000 participants from the Human Connectome Project. To further improve spatial modeling, we incorporate brain structure and function-informed edge attributes, i.e., the left/right hemispheric identity and subnetwork membership of brain regions, enabling the model to capture biologically meaningful topological patterns. We evaluate our BrainATCL on two tasks: functional link prediction and age estimation. The experimental results demonstrate superior performance and strong generalization, including in cross-session prediction scenarios.

脑连接时序建模图神经网络年龄估计

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