arXiv:2508.09160cs.LGcs.DB2025-08被引 6

构建15个数据集整合的糖尿病研究数据库,助力低血糖预警研究。

Presenting DiaData for Research on Type 1 Diabetes

  • 整合15个数据集,形成2510人、每5分钟记录一次的大型葡萄糖数据集。
  • 包含1.49亿条数据,其中4%为低血糖值(≤70 mg/dL)。
  • 提供性别与年龄均衡的数据,支持心率与血糖关联分析。

1型糖尿病(T1D)是一种自身免疫性疾病,导致胰岛素生成细胞破坏,引发胰岛素缺乏,患者需依赖外部胰岛素注射。然而,胰岛素可能降低血糖水平,引发低血糖(≤70 mg/dL),带来头晕、昏迷甚至死亡等严重后果。数据分析可显著提升糖尿病管理,通过识别个人模式和趋势预防不良事件。尤其机器学习模型可预测血糖并提前预警。但当前研究受限于大规模数据集的缺失。为此,本文系统整合15个数据集,构建包含2510名受试者、每5分钟记录一次的大型数据库,总计1.49亿条血糖测量数据,其中4%处于低血糖范围。同时提取两个子数据库:子库I含人口统计信息,子库II含心率数据。数据集实现性别与不同年龄层的均衡分布。进一步评估数据质量,发现数据不平衡与缺失值是主要挑战。相关性分析显示,心率与血糖在低血糖发生前15至55分钟存在关联。

原文摘要 · Abstract (English)

Type 1 diabetes (T1D) is an autoimmune disorder that leads to the destruction of insulin-producing cells, resulting in insulin deficiency, as to why the affected individuals depend on external insulin injections. However, insulin can decrease blood glucose levels and can cause hypoglycemia. Hypoglycemia is a severe event of low blood glucose levels ($\le$70 mg/dL) with dangerous side effects of dizziness, coma, or death. Data analysis can significantly enhance diabetes care by identifying personal patterns and trends leading to adverse events. Especially, machine learning (ML) models can predict glucose levels and provide early alarms. However, diabetes and hypoglycemia research is limited by the unavailability of large datasets. Thus, this work systematically integrates 15 datasets to provide a large database of 2510 subjects with glucose measurements recorded every 5 minutes. In total, 149 million measurements are included, of which 4% represent values in the hypoglycemic range. Moreover, two sub-databases are extracted. Sub-database I includes demographics, and sub-database II includes heart rate data. The integrated dataset provides an equal distribution of sex and different age levels. As a further contribution, data quality is assessed, revealing that data imbalance and missing values present a significant challenge. Moreover, a correlation study on glucose levels and heart rate data is conducted, showing a relation between 15 and 55 minutes before hypoglycemia.

糖尿病研究数据集低血糖预警机器学习

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