轻量模型+协作学习,实现嵌入式设备实时无创血压波形预测。
Collaborative Learning-Enhanced Lightweight Models for Predicting Arterial Blood Pressure Waveform in a Large-scale Perioperative Dataset
- 设计轻量sInvResUNet并结合协同学习提升性能。
- 0.89百万参数,0.02 GFLOPS,推理仅8.49毫秒。
- 在2154名患者的大规模数据上表现稳定,适合临床部署。
无创动脉血压(ABP)监测在危重症和围术期管理中至关重要,可连续评估心血管血流动力学且风险极低。已有大量深度学习模型尝试从心电图和光电容积脉搏波等非侵入信号重建ABP波形,但针对嵌入式系统部署时的模型性能与计算负载问题研究仍有限。本研究提出轻量级sInvResUNet模型,并引入协同学习方案KDCL_sInvResUNet。该模型仅含0.89百万参数,计算量为0.02 GFLOPS,可在嵌入式设备上实现实时ABP估计,10秒输出的推理时间仅为8.49毫秒。在包含2,154名患者、共1,257,141个数据片段的大型异质围术期数据集上进行独立受试者验证,收缩压范围41–257 mmHg,舒张压范围31–234 mmHg。所提KDCL_sInvResUNet在跟踪ABP变化上表现优于部分大模型,平均绝对误差为10.06 mmHg,皮尔逊相关系数达0.88。尽管结果令人鼓舞,所有深度学习模型在不同人口统计学及心血管条件下仍表现出显著性能差异,表明其跨人群泛化能力有限。本研究为真实围术期环境中实时、无创血压监测奠定了基础,也为后续发展提供了基准。
原文摘要 · Abstract (English)
Noninvasive arterial blood pressure (ABP) monitoring is essential for patient management in critical care and perioperative settings, providing continuous assessment of cardiovascular hemodynamics with minimal risks. Numerous deep learning models have developed to reconstruct ABP waveform from noninvasively acquired physiological signals such as electrocardiogram and photoplethysmogram. However, limited research has addressed the issue of model performance and computational load for deployment on embedded systems. The study introduces a lightweight sInvResUNet, along with a collaborative learning scheme named KDCL_sInvResUNet. With only 0.89 million parameters and a computational load of 0.02 GFLOPS, real-time ABP estimation was successfully achieved on embedded devices with an inference time of just 8.49 milliseconds for a 10-second output. We performed subject-independent validation in a large-scale and heterogeneous perioperative dataset containing 1,257,141 data segments from 2,154 patients, with a wide BP range (41-257 mmHg for SBP, and 31-234 mmHg for DBP). The proposed KDCL_sInvResUNet achieved lightly better performance compared to large models, with a mean absolute error of 10.06 mmHg and mean Pearson correlation of 0.88 in tracking ABP changes. Despite these promising results, all deep learning models showed significant performance variations across different demographic and cardiovascular conditions, highlighting their limited ability to generalize across such a broad and diverse population. This study lays a foundation work for real-time, unobtrusive ABP monitoring in real-world perioperative settings, providing baseline for future advancements in this area.
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