用扩散模型实现心脏体积的高效精准重建,无需额外标注。
Latent Interpolation Learning Using Diffusion Models for Cardiac Volume Reconstruction
- 基于扩散模型的数据驱动插值,捕捉稀疏切片间非线性关系。
- 在潜在空间操作,3D重建速度提升24倍,计算开销显著降低。
- 仅需少量2D图像即可完成高质量重建,适合临床实用场景。
心脏磁共振(CMR)成像是诊断心血管疾病的关键工具,但其应用常受限于短轴切片采集稀疏,导致三维体积信息不完整。从稀疏切片准确重建3D心脏结构对全面评估至关重要,但现有方法存在依赖预设插值方式(如线性或球形)、计算效率低、需额外语义输入(如分割标签或运动数据)等问题。为此,我们提出新型心脏潜在插值扩散框架(CaLID),引入三项创新:首先,基于扩散模型的数据驱动插值方案,可捕捉切片间的复杂非线性关系,提升重建精度;其次,设计一种在潜在空间运行的高效方法,使3D全心上采样时间提速24倍,显著降低计算开销;第三,仅以稀疏2D CMR图像为输入,即达到当前最优性能,无需形态学引导等辅助输入,简化工作流程。进一步将方法扩展至2D+T数据,有效建模时空动态并保证时序一致性。大量体积评估与下游分割任务验证表明,CaLID在重建质量与效率上均表现卓越。本框架克服了现有方法的根本局限,推动了时空全心重建的前沿进展,提供了一种鲁棒且临床可用的心血管成像解决方案。
原文摘要 · Abstract (English)
Cardiac Magnetic Resonance (CMR) imaging is a critical tool for diagnosing and managing cardiovascular disease, yet its utility is often limited by the sparse acquisition of 2D short-axis slices, resulting in incomplete volumetric information. Accurate 3D reconstruction from these sparse slices is essential for comprehensive cardiac assessment, but existing methods face challenges, including reliance on predefined interpolation schemes (e.g., linear or spherical), computational inefficiency, and dependence on additional semantic inputs such as segmentation labels or motion data. To address these limitations, we propose a novel Cardiac Latent Interpolation Diffusion (CaLID) framework that introduces three key innovations. First, we present a data-driven interpolation scheme based on diffusion models, which can capture complex, non-linear relationships between sparse slices and improves reconstruction accuracy. Second, we design a computationally efficient method that operates in the latent space and speeds up 3D whole-heart upsampling time by a factor of 24, reducing computational overhead compared to previous methods. Third, with only sparse 2D CMR images as input, our method achieves SOTA performance against baseline methods, eliminating the need for auxiliary input such as morphological guidance, thus simplifying workflows. We further extend our method to 2D+T data, enabling the effective modeling of spatiotemporal dynamics and ensuring temporal coherence. Extensive volumetric evaluations and downstream segmentation tasks demonstrate that CaLID achieves superior reconstruction quality and efficiency. By addressing the fundamental limitations of existing approaches, our framework advances the state of the art for spatio and spatiotemporal whole-heart reconstruction, offering a robust and clinically practical solution for cardiovascular imaging.
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