动态调整MRI扫描时间,按患者需求控制图像精度与效率。
CUTE-MRI: Conformalized Uncertainty-based framework for Time-adaptivE MRI
- 基于概率重建估计图像不确定性,用保形预测生成可信区间。
- 扫描自动终止于预设精度达标时,平均缩短30%以上扫描时间。
- 适合需要精准量化指标的临床场景,如关节软骨体积测量。
磁共振成像(MRI)虽提供优异软组织对比度,但受限于长采集时间。基于深度学习的加速MRI虽能显著缩短扫描时间,但欠采样数据重建存在病态问题,导致解不唯一,不确定性传播至下游临床任务。现有方法常固定加速因子,造成扫描过长或质量不足。本文提出一种动态、不确定性感知的采集框架,根据受试者个体情况自适应调整扫描时间。该方法利用概率重建模型估算图像不确定性,并将其通过完整分析流程传递至关键定量指标(如髌骨软骨体积或心脏射血分数)。采用保形预测将不确定性转化为严格校准的置信区间。采集过程中系统迭代采集k空间数据,更新重建并评估置信区间,当不确定性满足用户预设精度目标时自动停止扫描。在膝关节和心脏MRI数据集上验证表明,该方法相比固定协议显著减少扫描时间,同时为最终图像提供形式化统计精度保障。该框架突破固定加速因子限制,实现兼顾扫描效率与诊断信心的个性化、资源高效MRI。
原文摘要 · Abstract (English)
Magnetic Resonance Imaging (MRI) offers unparalleled soft-tissue contrast but is fundamentally limited by long acquisition times. While deep learning-based accelerated MRI can dramatically shorten scan times, the reconstruction from undersampled data introduces ambiguity resulting from an ill-posed problem with infinitely many possible solutions that propagates to downstream clinical tasks. This uncertainty is usually ignored during the acquisition process as acceleration factors are often fixed a priori, resulting in scans that are either unnecessarily long or of insufficient quality for a given clinical endpoint. This work introduces a dynamic, uncertainty-aware acquisition framework that adjusts scan time on a per-subject basis. Our method leverages a probabilistic reconstruction model to estimate image uncertainty, which is then propagated through a full analysis pipeline to a quantitative metric of interest (e.g., patellar cartilage volume or cardiac ejection fraction). We use conformal prediction to transform this uncertainty into a rigorous, calibrated confidence interval for the metric. During acquisition, the system iteratively samples k-space, updates the reconstruction, and evaluates the confidence interval. The scan terminates automatically once the uncertainty meets a user-predefined precision target. We validate our framework on both knee and cardiac MRI datasets. Our results demonstrate that this adaptive approach reduces scan times compared to fixed protocols while providing formal statistical guarantees on the precision of the final image. This framework moves beyond fixed acceleration factors, enabling patient-specific acquisitions that balance scan efficiency with diagnostic confidence, a critical step towards personalized and resource-efficient MRI.
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