7T MRI下用新方法实现均匀的T1、T2和质子密度成像。
Turbo Spin Echo Imaging at 7T with Bilateral Orthogonality Generative Acquisitions Method for Homogeneous T_1, T_2 and Proton Density Contrasts
- 用双正交生成采集法融合多组射频模式和扫描参数数据
- 消除7T磁共振成像中的场不均匀性，获得均匀对比度图像
- 适合需要高精度组织对比的脑部成像研究者
目的：将原本用于梯度回波T2*成像的双正交生成采集（BOGA）方法，适配于7特斯拉（7T）下的自旋回波成像（TSE），结合平行传输系统，以获得均匀的T1、T2及质子密度加权图像。理论与方法：采集多组具有互补射频发射/接收场不均匀性模式及不同回波时间、重复时间的TSE图像作为输入；通过在不同数据子集上应用BOGA方法，分别生成最终图像。结果表明，所获图像在无发射/接收场不均匀性影响下，实现了均匀的T1、T2及质子密度对比。同时使用两个不同TSE因子进行独立验证，通过归一化强度剖面和信噪比图比较了各模式图像及不同因子的影响。结论：在7T下，通过该方法可实现无场不均匀性干扰的均匀组织对比图像，且无需额外预采集数据即可完成。
原文摘要 · Abstract (English)
Purpose: Bilateral Orthogonality Generative Acquisitions (BOGA) method, which was initially implemented for T_2^* contrast via gradient echo acquisitions, is adapted for TSE imaging at 7T using parallel transmission (pTx) system for obtaining homogeneous T_1, T_2 and proton density weighted images. Theory and Methods: Multiple TSE images with complimentary RF modes and scan parameters are acquired as input images for the BOGA method where RF modes have complimentary transmit and receive field inhomogeneity patterns and scan parameters have varying echo and repetition times. With the application of the BOGA method using different subsets of the data acquisitions for each contrast, homogeneous T_1, T_2 and proton density contrast in the final images obtained. Furthermore, to demonstrate the effect of the TSE factor, two TSE factors are used individually. Normalized intensity profiles and signal to noise ratio maps are utilized for the comparison of the CP mode images and the TSE factors respectively. Results: Homogeneous T_1, T_2 and proton density weighted images are obtained with the TSE implementation of the BOGA method without the transmit and receive field inhomogeneity effects. Furthermore, mixed contrast effects of the TSE acquisition are simultaneously resolved independently of the TSE factor. Conclusion: TSE application of BOGA method results in homogeneous T_1, T_2 and proton density contrasts at 7T, as the inhomogeneity effects are removed from the final contrast without any prior data acquisitions.
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