首次揭示大模型代理中的时间检查到使用漏洞，提出检测与防御方案。

Large Language Model (LLM)-enabled agents are rapidly emerging across a wide range of applications, but their deployment introduces vulnerabilities with security implications. While prior work has examined prompt-based attacks (e.g., prompt injection) and data-oriented threats (e.g., data exfiltration), time-of-check to time-of-use (TOCTOU) remain largely unexplored in this context. TOCTOU arises when an agent validates external state (e.g., a file or API response) that is later modified before use, enabling practical attacks such as malicious configuration swaps or payload injection. In this work, we present the first study of TOCTOU vulnerabilities in LLM-enabled agents. We introduce TOCTOU-Bench, a benchmark with 66 realistic user tasks designed to evaluate this class of vulnerabilities. As countermeasures, we adapt detection and mitigation techniques from systems security to this setting and propose prompt rewriting, state integrity monitoring, and tool-fusing. Our study highlights challenges unique to agentic workflows, where we achieve up to 25% detection accuracy using automated detection methods, a 3% decrease in vulnerable plan generation, and a 95% reduction in the attack window. When combining all three approaches, we reduce the TOCTOU vulnerabilities from an executed trajectory from 12% to 8%. Our findings open a new research direction at the intersection of AI safety and systems security.