仅用卫星图像生成结构一致的人类流动数据，无需额外辅助信息。

Origin-Destination (OD) flow matrices are critical for urban mobility analysis, supporting traffic forecasting, infrastructure planning, and policy design. Existing methods face two key limitations: (1) reliance on costly auxiliary features (e.g., Points of Interest, socioeconomic statistics) with limited spatial coverage, and (2) fragility to spatial topology changes, where reordering urban regions disrupts the structural coherence of generated flows. We propose Sat2Flow, a structure-aware diffusion framework that generates structurally coherent OD flows using only satellite imagery. Our approach employs a multi-kernel encoder to capture diverse regional interactions and a permutation-aware diffusion process that maintains consistency across regional orderings. Through joint contrastive training linking satellite features with OD patterns and equivariant diffusion training enforcing structural invariance, Sat2Flow ensures topological robustness under arbitrary regional reindexing. Experiments on real-world datasets show that Sat2Flow outperforms physics-based and data-driven baselines in accuracy while preserving flow distributions and spatial structures under index permutations. Sat2Flow offers a globally scalable solution for OD flow generation in data-scarce environments, eliminating region-specific auxiliary data dependencies while maintaining structural robustness for reliable mobility modeling.