arXiv:2508.21320cs.AIcs.LG2025-08中稿 · as a full research…被引 5

融合多医学本体图谱,通过双轴传播提升医疗概念表示效果。

Multi-Ontology Integration with Dual-Axis Propagation for Medical Concept Representation

  • 利用大模型增强本体嵌入初始化,结合概念描述与上下文信息。
  • 在同源与跨源两个维度并行传播知识,捕捉层级与跨领域关联。
  • 在罕见病预测和小样本场景中表现更优,可直接接入现有EHR模型。

医学本体图谱通过结构化关系将外部知识映射到电子健康记录中的医疗编码。现有研究大多仅依赖单一本体系统或孤立处理多个本体系统(如疾病、药物、操作),未能构建统一学习结构,导致概念表示局限于本体内关系,忽视跨本体连接。本文提出LINKO,一种大语言模型增强的集成本体学习框架,通过在异构本体系统间实现双轴知识传播,同时支持本体内部的垂直传播与跨本体的水平传播,以增强医疗概念表示。首先,利用定制提示词(包含概念描述与本体上下文)引导大模型进行图检索增强的嵌入初始化。其次,联合学习不同本体图谱中的医疗概念,通过双重轴向传播实现知识融合。最后,在两个公开数据集上验证了其优于现有基线模型的性能。作为可插拔编码器,LINKO在数据稀缺和罕见病预测场景中展现出更强鲁棒性。

原文摘要 · Abstract (English)

Medical ontology graphs map external knowledge to medical codes in electronic health records via structured relationships. By leveraging domain-approved connections (e.g., parent-child), predictive models can generate richer medical concept representations by incorporating contextual information from related concepts. However, existing literature primarily focuses on incorporating domain knowledge from a single ontology system, or from multiple ontology systems (e.g., diseases, drugs, and procedures) in isolation, without integrating them into a unified learning structure. Consequently, concept representation learning often remains limited to intra-ontology relationships, overlooking cross-ontology connections. In this paper, we propose LINKO, a large language model (LLM)-augmented integrative ontology learning framework that leverages multiple ontology graphs simultaneously by enabling dual-axis knowledge propagation both within and across heterogeneous ontology systems to enhance medical concept representation learning. Specifically, LINKO first employs LLMs to provide a graph-retrieval-augmented initialization for ontology concept embedding, through an engineered prompt that includes concept descriptions, and is further augmented with ontology context. Second, our method jointly learns the medical concepts in diverse ontology graphs by performing knowledge propagation in two axes: (1) intra-ontology vertical propagation across hierarchical ontology levels and (2) inter-ontology horizontal propagation within every level in parallel. Last, through extensive experiments on two public datasets, we validate the superior performance of LINKO over state-of-the-art baselines. As a plug-in encoder compatible with existing EHR predictive models, LINKO further demonstrates enhanced robustness in scenarios involving limited data availability and rare disease prediction.

医学本体知识图谱大模型表示学习

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