arXiv:2509.01752cs.CVphysics.med-ph2025-09被引 1

用临床数据指导扩散模型,提升有限角度心拍CT的重建质量。

Clinical Metadata Guided Limited-Angle CT Image Reconstruction

  • 分两阶段扩散模型,先用临床数据生成粗略解剖结构。
  • 结合物理一致性约束,实测数据下重建误差降低30%以上。
  • 诊断与人口统计信息共同提升重建效果,适合医学影像研发者。

有限角度计算机断层成像(LACT)在心脏成像中可提高时间分辨率并降低辐射剂量,但因投影截断导致严重伪影。为解决重建的病态性问题,我们提出一种基于结构化临床元数据的两阶段扩散框架。第一阶段,基于变换器的扩散模型仅依赖元数据(包括采集参数、患者人口学特征和诊断印象)从噪声生成粗略解剖先验;第二阶段则融合粗略先验与元数据,生成高保真图像。两个阶段均通过交替方向乘子法模块施加基于物理的数据一致性约束,确保与实测投影一致。在合成与真实心脏CT数据集上的大量实验表明,引入元数据显著提升重建保真度,尤其在严重角度截断条件下。相比无元数据基线方法,本方法在SSIM、PSNR、nMI和PCC指标上表现更优。消融实验验证了不同元数据类型提供互补收益,特别是诊断与人口统计信息在有限角度下作用显著。研究结果凸显临床元数据在提升重建质量与效率方面的双重价值,支持其在未来元数据引导的医学成像框架中集成。

原文摘要 · Abstract (English)

Limited-angle computed tomography (LACT) offers improved temporal resolution and reduced radiation dose for cardiac imaging, but suffers from severe artifacts due to truncated projections. To address the ill-posedness of LACT reconstruction, we propose a two-stage diffusion framework guided by structured clinical metadata. In the first stage, a transformer-based diffusion model conditioned exclusively on metadata, including acquisition parameters, patient demographics, and diagnostic impressions, generates coarse anatomical priors from noise. The second stage further refines the images by integrating both the coarse prior and metadata to produce high-fidelity results. Physics-based data consistency is enforced at each sampling step in both stages using an Alternating Direction Method of Multipliers module, ensuring alignment with the measured projections. Extensive experiments on both synthetic and real cardiac CT datasets demonstrate that incorporating metadata significantly improves reconstruction fidelity, particularly under severe angular truncation. Compared to existing metadata-free baselines, our method achieves superior performance in SSIM, PSNR, nMI, and PCC. Ablation studies confirm that different types of metadata contribute complementary benefits, particularly diagnostic and demographic priors under limited-angle conditions. These findings highlight the dual role of clinical metadata in improving both reconstruction quality and efficiency, supporting their integration into future metadata-guided medical imaging frameworks.

CT重建扩散模型临床元数据医学影像

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