无需造影剂即可实现高分辨率微血管成像，提升清晰度与对比度。
Contrast-Free Ultrasound Microvascular Imaging via Radiality and Similarity Weighting
- 结合径向权重与相干性分析，提升空间分辨率并抑制噪声。
- 体内实验显示分辨率提高2至3倍，对比度提升最高达20 dB。
- 300毫秒至1.2秒内完成成像，适合临床和科研快速评估。
微血管成像因超快数据采集和滤波技术进步，显著提升了功率多普勒对小血管的敏感性。但图像质量仍受限于空间分辨率低和背景噪声高，影响可视化与定量分析。为此，本文提出一种高分辨率交叉相关功率多普勒（HR-XPD）方法，融合空间径向权重与多普勒信号相干性分析，在增强空间分辨率的同时有效抑制伪影和背景噪声。仿真与在健康人肝、移植人肾及猪肾的活体实验表明，与传统功率多普勒相比，HR-XPD显著提升微血管分辨力和对比度。活体结果中，空间分辨率最高提升2至3倍，对比度提升达20 dB。仅需0.3秒至1.2秒短时间采集，即可清晰呈现高分辨率血管细节，且无需使用造影剂。结果表明，该方法是一种高效、无造影剂、高分辨率的微血管成像新方案，具有广泛应用于临床和基础研究的潜力。
原文摘要 · Abstract (English)
Microvascular imaging has advanced significantly with ultrafast data acquisition and improved clutter filtering, enhancing the sensitivity of power Doppler imaging to small vessels. However, the image quality remains limited by spatial resolution and elevated background noise, both of which impede visualization and accurate quantification. To address these limitations, this study proposes a high-resolution cross-correlation Power Doppler (HR-XPD) method that integrates spatial radiality weighting with Doppler signal coherence analysis, thereby enhancing spatial resolution while suppressing artifacts and background noise. Quantitative evaluations in simulation and in vivo experiments on healthy human liver, transplanted human kidney, and pig kidney demonstrated that HR-XPD significantly improves microvascular resolvability and contrast compared to conventional PD. In vivo results showed up to a 2 to 3-fold enhancement in spatial resolution and an increase in contrast by up to 20 dB. High-resolution vascular details were clearly depicted within a short acquisition time of only 0.3 s-1.2 s without the use of contrast agents. These findings indicate that HR-XPD provides an effective, contrast-free, and high-resolution microvascular imaging approach with broad applicability in both preclinical and clinical research.
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