arXiv:2509.07772cs.CVcs.AI2025-09

用多模态AI提前预测中风复发风险,提升治疗针对性。

XSRD-Net: EXplainable Stroke Relapse Detection

  • 融合影像与临床数据的可解释神经网络,识别复发高危患者。
  • 复发预测模型在测试集上AUC达0.71,生存时间预测c-index为0.68。
  • 揭示心脏疾病与颈动脉异常的关联,助力临床决策。

中风是全球第二大死亡原因,每年致死约550万人,首年复发率在5%至25%之间,复发死亡率高达40%,因此降低复发至关重要。本文通过早期识别中风复发高风险患者以实现及时干预。研究收集了2010至2024年间患者的3D颅内CTA影像及伴随心脏病史、年龄、性别等信息,训练单模态与多模态深度学习模型,完成两类任务:任务1为二分类复发检测(仅使用表格数据,测试集AUC为0.84);任务2为复发无生存时间(RFS)预测与后续分类。主任务中,多模态XSRD-net按视觉:表格贡献比0.68:0.32融合数据,模型在复发预测上的c-index达到0.68,测试集分类AUC为0.71。进一步可解释性分析表明,心脏疾病(表格数据)与颈动脉异常(视觉数据)之间存在显著关联,对复发预测和生存期预估具有关键意义。该发现将通过持续数据积累与模型重训得到强化。

原文摘要 · Abstract (English)

Stroke is the second most frequent cause of death world wide with an annual mortality of around 5.5 million. Recurrence rates of stroke are between 5 and 25% in the first year. As mortality rates for relapses are extraordinarily high (40%) it is of utmost importance to reduce the recurrence rates. We address this issue by detecting patients at risk of stroke recurrence at an early stage in order to enable appropriate therapy planning. To this end we collected 3D intracranial CTA image data and recorded concomitant heart diseases, the age and the gender of stroke patients between 2010 and 2024. We trained single- and multimodal deep learning based neural networks for binary relapse detection (Task 1) and for relapse free survival (RFS) time prediction together with a subsequent classification (Task 2). The separation of relapse from non-relapse patients (Task 1) could be solved with tabular data (AUC on test dataset: 0.84). However, for the main task, the regression (Task 2), our multimodal XSRD-net processed the modalities vision:tabular with 0.68:0.32 according to modality contribution measures. The c-index with respect to relapses for the multimodal model reached 0.68, and the AUC is 0.71 for the test dataset. Final, deeper interpretability analysis results could highlight a link between both heart diseases (tabular) and carotid arteries (vision) for the detection of relapses and the prediction of the RFS time. This is a central outcome that we strive to strengthen with ongoing data collection and model retraining.

中风预测多模态可解释性临床决策

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