用机器学习预测脑电图电极下方是否影响语言,提升术前定位效率。
Machine Learning-Based Prediction of Speech Arrest During Direct Cortical Stimulation Mapping
- 融合脑区位置与功能连接的神经信号建模,捕捉局部与网络动态
- 模型在新受试者上达到0.87的ROC-AUC和0.57的PR-AUC
- 适合需要高效术前语言功能定位的神经外科研究者
确定语言相关脑区对靠近语言区的脑手术安全至关重要。尽管电刺激映射(ESM)仍是临床金标准,但其具有侵入性且耗时。为此,我们分析了16名受试者在执行语言任务时的颅内皮层脑电图(ECoG)数据,构建机器学习模型以直接预测每个电极下方脑区是否关键。通过独立于ESM获得的言语中断作为真实标签训练分类模型。该框架整合神经活动信号、解剖区域标签及功能连接特征,同时捕捉局部活动与网络级动态。结果表明,结合区域与连接特征的模型性能媲美全特征集,优于仅使用单一类型特征的模型。通过将试验级预测结果以直方图编码后输入MLP进行聚合,实现电极级分类。最优模型为试验级径向基函数核支持向量机结合基于MLP的聚合,对保留受试者表现出优异性能(ROC-AUC: 0.87,PR-AUC: 0.57)。这些发现凸显了结合空间与网络信息及非线性建模在术前功能定位中的价值。
原文摘要 · Abstract (English)
Identifying cortical regions critical for speech is essential for safe brain surgery in or near language areas. While Electrical Stimulation Mapping (ESM) remains the clinical gold standard, it is invasive and time-consuming. To address this, we analyzed intracranial electrocorticographic (ECoG) data from 16 participants performing speech tasks and developed machine learning models to directly predict if the brain region underneath each ECoG electrode is critical. Ground truth labels indicating speech arrest were derived independently from Electrical Stimulation Mapping (ESM) and used to train classification models. Our framework integrates neural activity signals, anatomical region labels, and functional connectivity features to capture both local activity and network-level dynamics. We found that models combining region and connectivity features matched the performance of the full feature set, and outperformed models using either type alone. To classify each electrode, trial-level predictions were aggregated using an MLP applied to histogram-encoded scores. Our best-performing model, a trial-level RBF-kernel Support Vector Machine together with MLP-based aggregation, achieved strong accuracy on held-out participants (ROC-AUC: 0.87, PR-AUC: 0.57). These findings highlight the value of combining spatial and network information with non-linear modeling to improve functional mapping in presurgical evaluation.
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