arXiv:2509.09153cs.CVcs.AI2025-09中稿 · manuscript of an a…

通过多尺度细胞与组织交互标注,提升病理图像中细胞检测的准确性。

OCELOT 2023: Cell Detection from Cell-Tissue Interaction Challenge

  • 构建六器官多尺度标注数据集,支持细胞与组织关系建模。
  • 最佳模型相较仅依赖细胞的基线模型提升7.99点F1分数。
  • 适合关注医学图像多尺度分析与细粒度检测的研究者。

病理学家在检查全切片图像时,会交替使用不同放大倍数来评估组织整体形态和细胞细节,从而形成全面诊断。然而,现有基于深度学习的细胞检测模型难以复现这一行为,也未能学习不同尺度结构间的相互依赖语义。该领域的一大障碍是缺乏具有多尺度重叠细胞与组织标注的数据集。为此,OCELOT 2023挑战赛旨在收集社区反馈,验证‘理解细胞与组织(细胞-组织)交互对达到人类水平性能至关重要’这一假设,并推动该方向研究。数据集包含来自6个器官、673对样本,源自306张TCGA全切片图像(H&E染色),分为训练、验证和测试集。参赛模型显著提升了对细胞-组织关系的理解。最优方案在测试集上相比不考虑细胞-组织关系的基线模型,F1分数最高提升7.99。这一显著性能提升证明,在模型中引入多尺度语义的必要性。本文对参赛方法进行了对比分析,突出展示了本次挑战赛中的创新策略。

原文摘要 · Abstract (English)

Pathologists routinely alternate between different magnifications when examining Whole-Slide Images, allowing them to evaluate both broad tissue morphology and intricate cellular details to form comprehensive diagnoses. However, existing deep learning-based cell detection models struggle to replicate these behaviors and learn the interdependent semantics between structures at different magnifications. A key barrier in the field is the lack of datasets with multi-scale overlapping cell and tissue annotations. The OCELOT 2023 challenge was initiated to gather insights from the community to validate the hypothesis that understanding cell and tissue (cell-tissue) interactions is crucial for achieving human-level performance, and to accelerate the research in this field. The challenge dataset includes overlapping cell detection and tissue segmentation annotations from six organs, comprising 673 pairs sourced from 306 The Cancer Genome Atlas (TCGA) Whole-Slide Images with hematoxylin and eosin staining, divided into training, validation, and test subsets. Participants presented models that significantly enhanced the understanding of cell-tissue relationships. Top entries achieved up to a 7.99 increase in F1-score on the test set compared to the baseline cell-only model that did not incorporate cell-tissue relationships. This is a substantial improvement in performance over traditional cell-only detection methods, demonstrating the need for incorporating multi-scale semantics into the models. This paper provides a comparative analysis of the methods used by participants, highlighting innovative strategies implemented in the OCELOT 2023 challenge.

细胞检测多尺度分析医学图像OCELOT

Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。