提出DCHO框架,动态预测多脑区复杂连接关系。
DCHO: A Decomposition-Composition Framework for Predicting Higher-Order Brain Connectivity to Enhance Diverse Downstream Applications
- 分-合框架将高阶连接预测拆解为特征提取与轨迹建模两步。
- 在多个数据集上显著优于现有方法,分类与预测任务均表现更优。
- 适合神经科学、脑机接口等需要动态脑网络建模的研究者。
高阶脑连接(HOBC)捕捉三个及以上脑区间的交互关系,相比传统成对功能连接(FC)提供更丰富的组织信息。近期研究开始从非侵入性影像数据推断潜在的HOBC,但主要集中在静态分析,限制了其在动态预测任务中的应用。为此,我们提出DCHO,一种基于分解-组合框架的统一方法,用于建模和预测HOBC的时序演化,适用于非预测任务(状态分类)与预测任务(脑动态预测)。DCHO采用分解-组合策略,将预测任务重构为两个可管理的子问题:HOBC推断与潜在轨迹预测。在推断阶段,提出双视角编码器以提取多尺度拓扑特征,并引入隐式组合学习器捕捉高层次的HOBC信息;在预测阶段,设计隐空间预测损失以增强时序轨迹建模能力。在多个神经影像数据集上的大量实验表明,DCHO在非预测任务(状态分类)与预测任务(脑动态预测)中均取得显著优于现有方法的性能。
原文摘要 · Abstract (English)
Higher-order brain connectivity (HOBC), which captures interactions among three or more brain regions, provides richer organizational information than traditional pairwise functional connectivity (FC). Recent studies have begun to infer latent HOBC from noninvasive imaging data, but they mainly focus on static analyses, limiting their applicability in dynamic prediction tasks. To address this gap, we propose DCHO, a unified approach for modeling and forecasting the temporal evolution of HOBC based on a Decomposition-Composition framework, which is applicable to both non-predictive tasks (state classification) and predictive tasks (brain dynamics forecasting). DCHO adopts a decomposition-composition strategy that reformulates the prediction task into two manageable subproblems: HOBC inference and latent trajectory prediction. In the inference stage, we propose a dual-view encoder to extract multiscale topological features and a latent combinatorial learner to capture high-level HOBC information. In the forecasting stage, we introduce a latent-space prediction loss to enhance the modeling of temporal trajectories. Extensive experiments on multiple neuroimaging datasets demonstrate that DCHO achieves superior performance in both non-predictive tasks (state classification) and predictive tasks (brain dynamics forecasting), significantly outperforming existing methods.
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