用迁移学习+频谱均衡,首次实现羊胎脑电睡眠分期自动识别
FetalSleepNet: A Transfer Learning Framework with Spectral Equalisation Domain Adaptation for Fetal Sleep Stage Classification
- 基于成人脑电预训练模型,结合频谱均衡域适应策略
- 准确率86.6%,宏平均F1达62.5%,显著优于直接迁移(仅18.7%)
- 轻量设计适合可穿戴设备,可推广至临床无创信号标注
本研究提出FetalSleepNet,首个用于羊胎脑电(EEG)睡眠分期的深度学习方法。在24只晚期妊娠羊胎儿大脑顶叶硬膜上安置电极采集EEG数据。采用源自成人脑电的轻量级神经网络,通过迁移学习在胎儿EEG上进行训练,并引入基于频谱均衡的域适应策略以缓解跨域差异。结果表明:直接迁移性能差,准确率仅18.7%;而全微调结合频谱均衡后,准确率达到86.6%,宏平均F1得分为62.5%,优于基准模型。FetalSleepNet是首个专为胎儿脑电睡眠分期设计的深度学习框架。其可作为标签引擎,支持大规模弱监督/半监督标注与知识蒸馏,推动临床更易获取的信号(如多普勒超声或心电图)的模型训练。轻量化设计使其适用于低功耗、实时、可穿戴式胎儿监测系统。
原文摘要 · Abstract (English)
Introduction: This study presents FetalSleepNet, the first published deep learning approach to classifying sleep states from the ovine electroencephalogram (EEG). Fetal EEG is complex to acquire and difficult and laborious to interpret consistently. However, accurate sleep stage classification may aid in the early detection of abnormal brain maturation associated with pregnancy complications (e.g. hypoxia or intrauterine growth restriction). Methods: EEG electrodes were secured onto the ovine dura over the parietal cortices of 24 late gestation fetal sheep. A lightweight deep neural network originally developed for adult EEG sleep staging was trained on the ovine EEG using transfer learning from adult EEG. A spectral equalisation-based domain adaptation strategy was used to reduce cross-domain mismatch. Results: We demonstrated that while direct transfer performed poorly, full fine tuning combined with spectral equalisation achieved the best overall performance (accuracy: 86.6 percent, macro F1-score: 62.5), outperforming baseline models. Conclusions: To the best of our knowledge, FetalSleepNet is the first deep learning framework specifically developed for automated sleep staging from the fetal EEG. Beyond the laboratory, the EEG-based sleep stage classifier functions as a label engine, enabling large scale weak/semi supervised labeling and distillation to facilitate training on less invasive signals that can be acquired in the clinic, such as Doppler Ultrasound or electrocardiogram data. FetalSleepNet's lightweight design makes it well suited for deployment in low power, real time, and wearable fetal monitoring systems.
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