arXiv:2509.12453cs.CV2025-09

提出分阶段框架,实现可变长度眼病预测,提升小数据下模型表现。

Two-Stage Decoupling Framework for Variable-Length Glaucoma Prognosis

  • 分两阶段:先自监督融合多数据集学特征,再用注意力机制处理不同长度序列。
  • 在OHTS和GRAPE数据集上准确率显著优于现有方法,且参数量更小。
  • 适合医疗时间序列建模、小样本疾病预测研究者参考。

青光眼是全球致盲的主要原因之一。精准的预后对识别高危患者、及时干预至关重要。现有方法多依赖固定长度的历史序列数据,灵活性差;且常用端到端模型,在青光眼数据量有限的情况下表现不佳。为此,本文提出两阶段解耦框架(TSDF)用于可变长度青光眼预后。第一阶段采用特征表示模块,利用自监督学习整合多个青光眼数据集进行训练,忽略标注信息差异,从而提升小规模数据集的特征学习能力。第二阶段引入基于注意力的时间聚合模块,有效处理不同长度的时序输入,实现灵活高效的数据利用。在两个基准数据集——眼压治疗研究(OHTS)与真实世界青光眼进展评估集成(GRAPE)上的实验表明,该方法在规模和临床场景差异显著的情况下仍具优异性能与鲁棒性。

原文摘要 · Abstract (English)

Glaucoma is one of the leading causes of irreversible blindness worldwide. Glaucoma prognosis is essential for identifying at-risk patients and enabling timely intervention to prevent blindness. Many existing approaches rely on historical sequential data but are constrained by fixed-length inputs, limiting their flexibility. Additionally, traditional glaucoma prognosis methods often employ end-to-end models, which struggle with the limited size of glaucoma datasets. To address these challenges, we propose a Two-Stage Decoupling Framework (TSDF) for variable-length glaucoma prognosis. In the first stage, we employ a feature representation module that leverages self-supervised learning to aggregate multiple glaucoma datasets for training, disregarding differences in their supervisory information. This approach enables datasets of varying sizes to learn better feature representations. In the second stage, we introduce a temporal aggregation module that incorporates an attention-based mechanism to process sequential inputs of varying lengths, ensuring flexible and efficient utilization of all available data. This design significantly enhances model performance while maintaining a compact parameter size. Extensive experiments on two benchmark glaucoma datasets:the Ocular Hypertension Treatment Study (OHTS) and the Glaucoma Real-world Appraisal Progression Ensemble (GRAPE),which differ significantly in scale and clinical settings,demonstrate the effectiveness and robustness of our approach.

青光眼时间序列自监督医疗预测

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