用大模型生成狗骨骼疾病可视化数据，解决罕见病数据不足问题。

It is well-established that more data generally improves AI model performance. However, data collection can be challenging for certain tasks due to the rarity of occurrences or high costs. These challenges are evident in our use case, where we apply AI models to a novel approach for visually documenting the musculoskeletal condition of dogs. Here, abnormalities are marked as colored strokes on a body map of a dog. Since these strokes correspond to distinct muscles or joints, they can be mapped to the textual domain in which large language models (LLMs) operate. LLMs have demonstrated impressive capabilities across a wide range of tasks, including medical applications, offering promising potential for generating synthetic training data. In this work, we investigate whether LLMs can effectively generate synthetic visual training data for canine musculoskeletal diagnoses. For this, we developed a mapping that segments visual documentations into over 200 labeled regions representing muscles or joints. Using techniques like guided decoding, chain-of-thought reasoning, and few-shot prompting, we generated 1,000 synthetic visual documentations for patellar luxation (kneecap dislocation) diagnosis, the diagnosis for which we have the most real-world data. Our analysis shows that the generated documentations are sensitive to location and severity of the diagnosis while remaining independent of the dog's sex. We further generated 1,000 visual documentations for various other diagnoses to create a binary classification dataset. A model trained solely on this synthetic data achieved an F1 score of 88% on 70 real-world documentations. These results demonstrate the potential of LLM-generated synthetic data, which is particularly valuable for addressing data scarcity in rare diseases. While our methodology is tailored to the medical domain, the insights and techniques can be adapted to other fields.