首个基于AI基础模型的食管胃连接部腺癌诊断系统，提升内镜筛查与分期准确性。

The early detection of esophagogastric junction adenocarcinoma (EGJA) is crucial for improving patient prognosis, yet its current diagnosis is highly operator-dependent. This paper aims to make the first attempt to develop an artificial intelligence (AI) foundation model-based method for both screening and staging diagnosis of EGJA using endoscopic images. In this cohort and learning study, we conducted a multicentre study across seven Chinese hospitals between December 28, 2016 and December 30, 2024. It comprises 12,302 images from 1,546 patients; 8,249 of them were employed for model training, while the remaining were divided into the held-out (112 patients, 914 images), external (230 patients, 1,539 images), and prospective (198 patients, 1,600 images) test sets for evaluation. The proposed model employs DINOv2 (a vision foundation model) and ResNet50 (a convolutional neural network) to extract features of global appearance and local details of endoscopic images for EGJA staging diagnosis. Our model demonstrates satisfactory performance for EGJA staging diagnosis across three test sets, achieving an accuracy of 0.9256, 0.8895, and 0.8956, respectively. In contrast, among representative AI models, the best one (ResNet50) achieves an accuracy of 0.9125, 0.8382, and 0.8519 on the three test sets, respectively; the expert endoscopists achieve an accuracy of 0.8147 on the held-out test set. Moreover, with the assistance of our model, the overall accuracy for the trainee, competent, and expert endoscopists improves from 0.7035, 0.7350, and 0.8147 to 0.8497, 0.8521, and 0.8696, respectively. To our knowledge, our model is the first application of foundation models for EGJA staging diagnosis and demonstrates great potential in both diagnostic accuracy and efficiency.