arXiv:2509.17726cs.CVcs.LG2025-09被引 2

用深度学习自动标注脑动脉,还能给出置信度,提升诊断可靠性。

Automated Labeling of Intracranial Arteries with Uncertainty Quantification Using Deep Learning

  • 基于3D ToF-MRA图像,用nnUNet实现自动化血管标注。
  • 平均Dice得分0.922,表面距离0.387毫米,复杂血管也稳定可靠。
  • 生成不确定性图,帮助识别模糊或异常区域,适合临床部署。

准确标注颅内动脉对脑血管诊断和血流动力学分析至关重要,但传统方法耗时且依赖操作者差异。本文提出一种基于深度学习的自动标注框架,利用35例3D时间飞跃磁共振血管成像(3D ToF-MRA)分割数据,集成不确定性量化以增强可解释性与可靠性。评估了三种卷积神经网络:(1) 带残差编码器的UNet,作为常见基线;(2) CS-Net,融合通道与空间注意力机制,提升曲线结构识别能力;(3) nnUNet,可自适应调整预处理、训练及架构以适配数据特征。其中nnUNet表现最佳(平均Dice分数0.922,平均表面距离0.387毫米),在解剖复杂血管中更具鲁棒性。通过测试时增强(TTA)和新型坐标引导策略降低插值误差,生成的不确定性图能有效反映解剖模糊、病理变异或人工标注不一致区域。进一步在共注册4D Flow MRI数据上对比自动与手动标注的血流速度,结果无统计学差异,验证了临床实用性。该框架提供了一种可扩展、精准且具备不确定性感知能力的自动脑血管标注方案,支持后续血流分析并促进临床应用。

原文摘要 · Abstract (English)

Accurate anatomical labeling of intracranial arteries is essential for cerebrovascular diagnosis and hemodynamic analysis but remains time-consuming and subject to interoperator variability. We present a deep learning-based framework for automated artery labeling from 3D Time-of-Flight Magnetic Resonance Angiography (3D ToF-MRA) segmentations (n=35), incorporating uncertainty quantification to enhance interpretability and reliability. We evaluated three convolutional neural network architectures: (1) a UNet with residual encoder blocks, reflecting commonly used baselines in vascular labeling; (2) CS-Net, an attention-augmented UNet incorporating channel and spatial attention mechanisms for enhanced curvilinear structure recognition; and (3) nnUNet, a self-configuring framework that automates preprocessing, training, and architectural adaptation based on dataset characteristics. Among these, nnUNet achieved the highest labeling performance (average Dice score: 0.922; average surface distance: 0.387 mm), with improved robustness in anatomically complex vessels. To assess predictive confidence, we implemented test-time augmentation (TTA) and introduced a novel coordinate-guided strategy to reduce interpolation errors during augmented inference. The resulting uncertainty maps reliably indicated regions of anatomical ambiguity, pathological variation, or manual labeling inconsistency. We further validated clinical utility by comparing flow velocities derived from automated and manual labels in co-registered 4D Flow MRI datasets, observing close agreement with no statistically significant differences. Our framework offers a scalable, accurate, and uncertainty-aware solution for automated cerebrovascular labeling, supporting downstream hemodynamic analysis and facilitating clinical integration.

脑血管深度学习不确定性医学影像

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