小数据训练的图像块扩散模型显著提升低采样MRI重建质量,更受放射科医生青睐。
Patch-Based Diffusion for Data-Efficient, Radiologist-Preferred MRI Reconstruction
- 基于图像块的扩散模型,仅需25张相空间数据即可学习有效先验
- 在7倍欠采样下,图像质量(PSNR/SSIM/NRMSE)优于现有方法
- 三名放射科医生盲评中91.7%选择其重建结果为诊断更优
磁共振成像(MRI)采集时间长,导致成本高、可及性差,且易受运动伪影影响。基于扩散的概率模型可通过学习数据驱动先验来缩短采集时间,但通常需要大量训练数据,而真实数据集收集成本高昂。基于图像块的扩散模型在小规模真实数据上已展现出学习有效先验的潜力,但在MRI临床应用尚未验证。本文将图像块扩散逆求解器(PaDIS)扩展至复数多线圈MRI重建,并在FastMRI脑部数据集上,针对7倍欠采样重建与当前最优全图扩散基线(FastMRI-EDM)进行对比。结果显示,仅用25张相空间图像训练的PaDIS-MRI模型,在图像质量指标(PSNR、SSIM、NRMSE)、像素级不确定性、跨对比度泛化能力以及对严重欠采样的鲁棒性方面均优于基线。在三位放射科医生的盲评中,PaDIS-MRI重建在91.7%的病例中被判定为诊断更优,显著优于(i)FastMRI-EDM和(ii)基于小波稀疏性的经典凸优化重建。这些发现表明,基于图像块的扩散先验在数据稀缺但需高诊断信心的临床场景中具有巨大潜力。
原文摘要 · Abstract (English)
Magnetic resonance imaging (MRI) requires long acquisition times, raising costs, reducing accessibility, and making scans more susceptible to motion artifacts. Diffusion probabilistic models that learn data-driven priors can potentially assist in reducing acquisition time. However, they typically require large training datasets that can be prohibitively expensive to collect. Patch-based diffusion models have shown promise in learning effective data-driven priors over small real-valued datasets, but have not yet demonstrated clinical value in MRI. We extend the Patch-based Diffusion Inverse Solver (PaDIS) to complex-valued, multi-coil MRI reconstruction, and compare it against a state-of-the-art whole-image diffusion baseline (FastMRI-EDM) for 7x undersampled MRI reconstruction on the FastMRI brain dataset. We show that PaDIS-MRI models trained on small datasets of as few as 25 k-space images outperform FastMRI-EDM on image quality metrics (PSNR, SSIM, NRMSE), pixel-level uncertainty, cross-contrast generalization, and robustness to severe k-space undersampling. In a blinded study with three radiologists, PaDIS-MRI reconstructions were chosen as diagnostically superior in 91.7% of cases, compared to baselines (i) FastMRI-EDM and (ii) classical convex reconstruction with wavelet sparsity. These findings highlight the potential of patch-based diffusion priors for high-fidelity MRI reconstruction in data-scarce clinical settings where diagnostic confidence matters.
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